The development of in vitro carcinogenesis model, and the elucidation of mechanism of gastric and intestinal phenotypes aiming at the clinical application

2020 Fiscal Year Final Research Report

• Project/Area Number: 17K09355
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Nagoya City University
• Principal Investigator: MIZOSHITA Tsutomu 名古屋市立大学, 医薬学総合研究院(医学), 研究員 (40347414)
• Co-Investigator(Kenkyū-buntansha): 片野 敬仁 名古屋市立大学, 医薬学総合研究院(医学), 助教 (50768372) ; 城 卓志 名古屋市立大学, 医薬学総合研究院(医学), 名誉教授 (30231369)
• Project Period (FY): 2017-04-01 – 2021-03-31
• Keywords: in vitro 三次元培養系 / 炎症性腸疾患 / 潰瘍性大腸炎 / クローン病 / 腸管ベーチェット病

Outline of Final Research Achievements

The establishment of the in vitro carcinogenesis model enables the dynamic, chronological, and real-time analyses of the alimentary canal mucosa duct and is thought to be particularly important to the elucidation of the mechanism of "the cancerogenesis from chronic inflammation". It is important to perform the immunosuppressive treatment including anti-TNF-α antibodies for the refractory inflammatory bowel diseases (ulcerative colitis, Crohn's disease, intestinal Behcet's disease) in consideration of the history of treatment of the case and clinical course.

Free Research Field

消化器内科

Academic Significance and Societal Importance of the Research Achievements

in vitro発癌モデルの確立により、in vivoの実験に用いる実験動物の数を最小限に留めることが可能となり、動物愛護の観点から社会的にも大変意義深い。また、抗TNF-α抗体製剤を含めた免疫抑制治療は高額になることが多く、これらの治療を適切に行うことが医療経済学上も重要である。