2019 Fiscal Year Final Research Report
Development of novel therapeutic regimens for Helicobacter pylori infection by Light Emission Diode light irradiation
| Project/Area Number |
17K09478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
猪股 雅史 大分大学, 医学部, 教授 (60315330)
衛藤 剛 大分大学, 医学部, 准教授 (00404369)
井上 高教 大分大学, 理工学部, 准教授 (40243969)
山岡 吉生 大分大学, 医学部, 教授 (00544248)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | ピロリ菌治療 / 光線照射 / 内視鏡外科学 |
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| Outline of Final Research Achievements |
Irradiation of blue LEDs had a killing effect on antibiotic-resistant H. pylori strains against Amoxicillin, Clarithromycin, Levofloxacin, and Metronidazole, and one susceptible Helicobacter pylori (H. pylori) strain. It was found that H. pylori increased ROS production in H. pylori as a mechanism by which H. pylori was accompanied by morphological changes during the death process.
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| Free Research Field |
医歯薬学
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| Academic Significance and Societal Importance of the Research Achievements |
1．複数のピロリ菌株への青色LED光線照射により死滅効果が確認でき、薬物療法を代替する治療あるいはその補助療法として臨床応用が期待できる。
2．薬剤耐性株に対しても死滅効果が確認できたため、薬剤耐性ピロリ菌感染者に対する新規治療法の足掛かりとなりうる。
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