• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2019 Fiscal Year Final Research Report

Identification of gut microbiota- derived metabolites and the mechanisms that impair glucose metabolism

Research Project

  • PDF
Project/Area Number 17K09821
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Metabolomics
Research InstitutionUniversity of Toyama

Principal Investigator

Fujisaka Shiho  富山大学, 学術研究部医学系, 助教 (30512082)

Co-Investigator(Kenkyū-buntansha) 戸辺 一之  富山大学, 学術研究部医学系, 教授 (30251242)
薄井 勲  獨協医科大学, 医学部, 教授 (50377272)
Project Period (FY) 2017-04-01 – 2020-03-31
Keywordsインスリン抵抗性 / 腸内細菌
Outline of Final Research Achievements

We analyzed plasma and cecal metabolomics data of genetically different mice treated with a high fat- diet and/or antibiotics and identified several metabolites that correlated with insulin resistance of the host(Fujisaka et al. Cell Reports. 22: 3072-3086, 2018). We also reported that Bofutsushosan (BFT), a Japanese herbal medicine which has been clinically used for constipation in Asian countries, ameliorates glucose metabolism in mice with diet-induced obesity. As the mechanism, we found that BFT modified the gut microbiota, which may contribute to improving gut barrier function and preventing metabolic endotoxemia, leading to attenuation of diet-induced inflammation and glucose intolerance (Fujisaka et al. Sci. Rep. 10: 5544, 2020).

Free Research Field

糖代謝

Academic Significance and Societal Importance of the Research Achievements

肥満やメタボリック症候群の人口は近年世界的に増加しており、その合併症を引き起こすインスリン抵抗性の病態を克服することは喫緊の課題である。本研究を通じ、腸内細菌叢が血中の代謝産物の量に大きな影響を及ぼし、それがインスリン抵抗性の病態に大きく関与することを見出した。また、漢方薬である防風通聖散が、腸内細菌叢を変化させることでインスリン抵抗性の病態を改善しうる多面的作用があることを見出した。インスリン抵抗性を制御する上での腸内細菌叢の新たな役割を明らかにできたと考えられる。

URL: 

Published: 2021-02-19  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi