The role of Wnt and (pro)renin receptor signal in progressive nephritis

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K10143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Pediatrics
• Research Institution: The University of Tokushima
• Principal Investigator: URUSHIHARA Maki 徳島大学, 病院, 講師 (50403689)
• Co-Investigator(Kenkyū-buntansha): 香美 祥二 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (00224337)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: レニン / 進行性腎炎 / Wnt

Outline of Final Research Achievements

We investigated the novel mechanism of glomerular injury via (pro)renin receptor in renin-angiotensin system activation. We found that the expression levels of (pro)renin receptor and Wnt signal in glomeruli are elevated during the course of rat progressive nephritis model. In addition, cultured mesangial cells showed the increased inflammatory cytokine through (pro)renin receptor with Wnt signaling. Those results suggest that the focus on the mechanism in (pro)renin receptor would provide the effective therapeutic strategy in progression of glomerulonephritis.

Free Research Field

内科系臨床医学

Academic Significance and Societal Importance of the Research Achievements

研究成果は腎炎が進展する新しい機序を解明したものであり、これらの研究成果を元に従来にないより効果的な治療法が開発されれば腎炎による腎機能悪化を防ぐことができる。人工透析や腎移植に進行する患者に健康な生活をしてもらうことにより医療費を抑制するとともに社会貢献にもつながると期待できる。