2019 Fiscal Year Final Research Report
Pathological involvement of the neuroimmune cycle in skin allergic diseases
| Project/Area Number |
17K10242
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Dermatology
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
Otsuka Atsushi 京都大学, 医学研究科, 特定准教授 (60582054)
|
|---|
| Project Period (FY) |
2017-04-01 – 2020-03-31
|
| Keywords | 皮膚アレルギー疾患 |
|---|
| Outline of Final Research Achievements |
It is widely known that itching of the skin is mediated by the peripheral nerves. However, recent studies have shown that peripheral nerves interact with immune cells and may be involved in the pathogenesis of skin allergic diseases. In this research question, we investigated the role of peripheral nerves in cutaneous allergic diseases. The results showed that neuropeptides released from peripheral nerves are involved in contact dermatitis.
Translated with www.DeepL.com/Translator (free version)
|
| Free Research Field |
皮膚免疫学
|
| Academic Significance and Societal Importance of the Research Achievements |
皮膚アレルギー疾患における末梢神経の関与を明らかにした。本研究結果により、難治性の皮膚アレルギー疾患では神経ペプチドを標的とした新規治療法の開発が期待される。また、これまで知られていなかった末梢神経の働きを皮膚アレルギー疾患で明らかにしたことに学術的意義がある。
|
