2020 Fiscal Year Final Research Report

Quantification and biological backgrounds of depressive mixed state

Research Project

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Project/Area Number	17K10311
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Psychiatric science
Research Institution	University of the Ryukyus
Principal Investigator	Kondo Tsuyoshi 琉球大学, 医学(系)研究科(研究院), 教授 (40215455)
Co-Investigator(Kenkyū-buntansha)	三原一雄琉球大学, 医学(系)研究科(研究院), 客員研究員 (30302029) 甲田宗良琉球大学, 医学(系)研究科(研究院), 助教 (50736189) 新里輔鷹琉球大学, 医学(系)研究科(研究院), 助教 (20838057)
Project Period (FY)	2017-04-01 – 2021-03-31
Keywords	抑うつ性混合状態 / 定量的評価 / 破壊的な感情/行動 / 重症度 / 双極性 / 若年 / スクリーニング
Outline of Final Research Achievements	Depressive mixed state (DMX) in patients with major depressive episode was examined using the 12-item quantification scale for DMX (DMX-12) developed by us. Main DMX symptoms were hypersensitivity, racing/crowded thought, distractibility, overreaction, and inner tension. Severely depressed younger subjects with potential bipolarity are more likely to develop DMX, especially with disruptive emotion/behavior symptoms. Selected 8 symptoms from the DMX-12 may be helpful in screening of DMX with considerable severity since it well differentiates individuals with mixed depression or mixed features during major depressive episode from non-mixed patients, with the same cut-off and excellent sensitivity/negative predictive value.
Free Research Field	臨床精神医学
Academic Significance and Societal Importance of the Research Achievements	過少診断されやすい抑うつ性混合状態が、我々が開発したDMX-12により重症度が数値化され、一定の重症度を持った抑うつ性混合状態のスクリーニングが可能となった点で、臨床的な診断意義は大きい。本スクリーニングの使用により、陰性例では十分な抗うつ薬治療を安全に進め、陽性例では抑うつ性混合状態の診断的な面接に進み、抗うつ薬を回避した薬物選択（気分安定薬や非定型抗精神病薬の導入）を合理的に選択することが可能となり、治療の質の向上や薬効判定にも寄与する点で社会的意義も大きい。