2019 Fiscal Year Final Research Report
Effects of Dysbiosis and intestinal bacterial metabolites on carcinogenesis of CAC
| Project/Area Number |
17K10627
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Digestive surgery
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
今野 弘之 浜松医科大学, 医学部, 学長 (00138033)
山本 真義 浜松医科大学, 医学部, 助教 (70397420)
原田 岳 浜松医科大学, 医学部附属病院, 診療助教 (00537251)
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| Project Period (FY) |
2017-04-01 – 2020-03-31
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| Keywords | 炎症性腸疾患 / 発癌 / 腸内細菌 |
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| Outline of Final Research Achievements |
In the past surgical cases, the condition of FFPE specimens was worse than expected and the DNA quality was poor. Therefore, it was necessary to exclude such cases and we could not reach the target number of cases. In addition, the data of the next-generation sequencer did not reveal any difference in the components of the intestinal flora between IBD cases without cancer and CAC cases, and no bacterial species specific to CAC cases were identified.
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| Free Research Field |
下部消化管悪性腫瘍
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| Academic Significance and Societal Importance of the Research Achievements |
CAC症例は増加傾向にあり，その発癌メカニズム解明と予防法の確立はIBD患者の予後向上のための喫緊の課題である．現在のところCAC特異的な腸内細菌叢の変化，およびMetaboliteの変化は同定することができていないが，脂質代謝変化などの興味深い知見は得られているため，今後もさらに解析を続けていく予定である．
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