2021 Fiscal Year Final Research Report
Clinical evaluation of blood coagulation based on dielectric permittivity measurement: a study in cardiac surgery.
| Project/Area Number |
17K11073
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Anesthesiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Yamamoto Yudai 東京医科歯科大学, 東京医科歯科大学病院, 助教 (50710026)
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| Co-Investigator(Kenkyū-buntansha) |
内田 篤治郎 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (40262183)
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| Project Period (FY) |
2017-04-01 – 2022-03-31
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| Keywords | 血液凝固 / 誘電率 / トロンビン / フィブリノーゲン / 連銭形成 |
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| Outline of Final Research Achievements |
The dielectric coagulometer is a blood coagulation assay device that measures changes in dielectric permittivity. In this study of cardiovascular surgery, it was shown that erythrocyte rouleau formation measured by dielectric coagulometry predict plasma fibrinogen concentration as well as rotational thromboelastometry. Dielectric coagulometry with tissue factor stimulating reagents has the potential to measure thrombin generation. In addition, the relationship between tissue factor pathway inhibitor and decreased thrombin generation was demonstrated. Plasminogen activator inhibitor-1 after cardiopulmonary bypass tended to be associated with duration of cardiopulmonary bypass time.
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| Free Research Field |
麻酔科学
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| Academic Significance and Societal Importance of the Research Achievements |
本研究により、心臓血管外科手術において誘電コアグロメーターはフィブリノーゲン濃度の予測やトロンビン生成能の変化の測定が可能であることが示唆され、血液凝固障害の診断への臨床応用が期待される。また、血液の組織因子への反応性が組織因子経路インヒビター(tissue factor pathway inhibitor: TFPI) により抑制されているような状態が考えられ、TFPIの中和など、新たな治療的な介入の提案につなげていくことができると考えられる。また、直接経口抗凝固薬の薬効作用など、トロンビン生成能に影響を与える薬剤の薬効評価への応用などが期待される。
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