Identification of the relationship and its mechanism between cardiac arrest and underlying sarcopenia

2022 Fiscal Year Final Research Report

• Project/Area Number: 17K11577
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Emergency medicine
• Research Institution: Kyushu University
• Principal Investigator: Mitsuhiro Fukata 九州大学, 大学病院, 助教 (70795046)
• Co-Investigator(Kenkyū-buntansha): 赤星 朋比古 九州大学, 医学研究院, 准教授 (20336019)
• Project Period (FY): 2017-04-01 – 2023-03-31
• Keywords: Sarcopenia / Sudden death / Atrial fibrillation

Outline of Final Research Achievements

In patients with non-traumatic cardiac arrest, the presence of sarcopenia, as estimated by skeletal muscle area, was significantly associated with survival at 24 hours. In patients with atrial fibrillation who underwent catheter ablation, pectoral muscle area/body surface area was associated with an increased rate of the recurrence of atrial fibrillation in women. Serum myokine was measured in patients with atrial fibrillation, and somatomedin C was significantly correlated with 5m walking speed, but age was considered a confounding factor; Myostatin was significantly associated with 5m walking speed after age correction and may be useful as a marker of sarcopenia in patients with cardiac disease.

Free Research Field

循環器

Academic Significance and Societal Importance of the Research Achievements

骨格筋量が心停止患者の予後や、心房細動の再発に関わっていた。サルコペニアと心疾患の重篤性に関連があり、骨格筋量を維持することで心臓病の重篤化を防ぐことができる可能性が明らかとなり、その血液マーカーとしてマイオスタチンが有用である可能性が示された。近年、筋肉量を維持することが健康寿命を延長させることがわかってきたが、本研究はその機序を解明する一助となると考えられる。