2023 Fiscal Year Final Research Report

Learning Dementia Prevention Measures from Northern Thailand, Where There Are Few Dementia Cases: Based on the Relationship Between Cerebral Blood Flow and Lifestyle

Research Project

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Project/Area Number	17K12534
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Community health nursing
Research Institution	Toyama Prefectural University (2021-2023) Ishikawa Prefectural Nursing University (2017-2020)
Principal Investigator	Shimizu Nobuko 富山県立大学, 看護学部, 准教授 (20722622)
Co-Investigator(Kenkyū-buntansha)	松永昌宏愛知医科大学, 医学部, 准教授 (00533960) 長谷川昇同志社女子大学, 看護学部, 特任教授 (10156317) 梅村朋弘愛知医科大学, 医学部, 講師 (10401960) 山田恭子佛教大学, 保健医療技術学部, 教授 (20191314) 望月美也子京都文教短期大学, 食物栄養学科, 准教授 (20367858) 加藤真弓愛知医療学院短期大学, 理学療法学専攻, 教授 (90512856)
Project Period (FY)	2017-04-01 – 2024-03-31
Keywords	タイ人高齢者 / 日本人高齢者 / 近赤外分光法（NIRS） / 二重課題 / WHO-QOL / 認知機能評価 / 社会的孤立感 / 老年期抑うつ尺度
Outline of Final Research Achievements	The subjects were older adults attending senior salons in Thailand and Japan. The study was approved by the University Ethics Review Committee of the researcher's university.Multiple regression analysis of the results of 144 senior subjects (57 in Thailand and 87 in Japan), with cognitive function (MMSE, MoCA) as the dependent variable, showed that the combined Thai and Japanese senior had better GDS test scores (β=-.211, P=.015), higher Social-WHOQOL (β=. 209, P=.016), and better MMSE (β=-.209, P=.016), there was also an association between the LSNS-6 and MMSE values (β=.306, P=.021) among Thai seniors. Blood flow in the dorsolateral prefrontal cortex during word fluency and motor task performance (DT) was significantly associated (β=.412, P=.001) in the left dorsolateral prefrontal region in both countries.
Free Research Field	公衆衛生看護学
Academic Significance and Societal Importance of the Research Achievements	本研究の結果から、タイと日本の高齢者において、うつ病と社会的QOLが認知機能に影響を及ぼすこと、また、タイの高齢者では、日本よりも社会的孤立が認知機能に悪影響を及ぼすことが示された。特に、高齢者のうつ病と社会的孤立を早期に発見し、予防的介入を行うことが認知機能低下の予防に有効である。本研究は、二重課題実施中の背外側前頭前皮質活動の低下が、両国において将来の認知機能低下を予測する可能性を示唆していた。