Establishment of rat model in patellofemoral osteoarthritis and histopathological changes induced by mechanical load

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K13051
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kanazawa University
• Principal Investigator: Takahashi Ikufumi 金沢大学, 附属病院, 理学療法士 (30743835)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 変形性膝関節症 / 関節軟骨 / 滑膜 / 膝蓋下脂肪体 / 非荷重環境 / 組織学

Outline of Final Research Achievements

The purpose of this study was to examine the following three things histologically.; ①Establishment of osteoarthritis (OA) rat model in patellofemoral joint induced by MIA, ②Effect of joint loading on the progression of OA, ③Effect of unloading environment on joint compoenents.
As a result, this study revealed the following findings.; ① Intra-articular injection of MIA induced the typical histological changes in the patellofemoral joint, ② Joint unloading inhibits articular cartilage degeneration in knee joint, ③ Unloading environment caused disuse histological changes in the articular cartilage, however, it caused no critical histological changes to the synovial membrane or infrapatellar fat pad.

Free Research Field

理学療法学

Academic Significance and Societal Importance of the Research Achievements

本研究は「研究成果の概要」に述べた3つの点を組織学的に明らかにした。本研究で得られた新たな知見はいずれも理学療法分野で不足していた運動器における組織学的エビデンスを構築するものである。したがって、今後エビデンスに基づいた理学療法の確立に寄与するものであり、臨床上での治療に有益な知見であると考える。