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2017 Fiscal Year Research-status Report

臨床試験ビッグデータによる個別化医療:個人データメタアナリシスの方法的実践的研究

Research Project

Project/Area Number 17K19808
Research InstitutionKyoto University

Principal Investigator

古川 壽亮  京都大学, 医学研究科, 教授 (90275123)

Co-Investigator(Kenkyū-buntansha) 渡辺 範雄  京都大学, 医学研究科, 准教授 (20464563)
田中 司朗  京都大学, 医学研究科, 特定教授 (60522406)
野間 久史  統計数理研究所, データ科学研究系, 准教授 (70633486)
Project Period (FY) 2017-06-30 – 2020-03-31
Keywords臨床疫学 / メタアナリシス
Outline of Annual Research Achievements

今年度は研究計画に従い、さざままなデータセットをもとに個人データメタアナリシス、および個人データネットワークメタアナリシスを実施した。
Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JP, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JP & Geddes JR (2018) Comparative efficacy and acceptability of first- and second-generation antidepressants in the acute treatment of major depressive disorder: A network meta-analysis. The Lancet.
Furukawa TA, Maruo K, Noma H, Tanaka S, Imai H, Shinohara K, Ikeda K, Yamawaki S, Levine SZ, Goldberg Y, Leucht S & Cipriani A (in press) Initial severity of major depression and efficacy of new generation antidepressants: Individual-participant data meta-analysis. Acta Psychiatrica Scandinavica.
が受理された。ほかに数本の論文を投稿中である。//Cognitive-behavioral analysis system of psychotherapy (CBASP), drug, or their combination for persistent depressive disorder: Personalizing the treatment choice using individual participant data network meta-regression (submitted)// Efficient Two-Step Multivariate Random Effects Meta-Analysis of Individual Participant Data for Longitudinal Clinical Trials Using Mixed Effects Models (submitted)

Current Status of Research Progress
Current Status of Research Progress

1: Research has progressed more than it was originally planned.

Reason

本研究領域から初年度の段階で2本のpeer review論文の受理を得、さらに数本の論文を投稿中である。

Strategy for Future Research Activity

現在投稿中の論文の受理を目指すとともに、現在執筆中の「世界で行われてきたうつ病の認知行動療法、抗うつ剤、両者の併用、およびピルプラセボを比較した全ての臨床試験5本、約1000人の個人データを元に、IPD-NMAを実施する」プロトコルを完成させる。

Causes of Carryover

投稿中の論文について、受理にまだ至っていないため、投稿料が次年度に繰り越しになった

  • Research Products

    (3 results)

All 2018 Other

All Int'l Joint Research (1 results) Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results)

  • [Int'l Joint Research] University of Oxford(United Kingdom)

    • Country Name
      United Kingdom
    • Counterpart Institution
      University of Oxford
  • [Journal Article] Initial severity of major depression and efficacy of new generation antidepressants: Individual-participant data meta-analysis2018

    • Author(s)
      Furukawa TA, Maruo K, Noma H, Tanaka S, Imai H, Shinohara K, Ikeda K, Yamawaki S, Levine SZ, Goldberg Y, Leucht S & Cipriani A
    • Journal Title

      Acta Psychiatrica Scandinavica

      Volume: epub Pages: 1-8

    • DOI

      10.1111/acps.12886

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Comparative efficacy and acceptability of first- and second-generation antidepressants in the acute treatment of major depressive disorder: A network meta-analysis.2018

    • Author(s)
      Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, Leucht S, Ruhe HG, Turner EH, Higgins JP, Egger M, Takeshima N, Hayasaka Y, Imai H, Shinohara K, Tajika A, Ioannidis JP & Geddes JR
    • Journal Title

      Lancet

      Volume: epub Pages: 1-8

    • DOI

      10.1016/ S0140-6736(17)32802-7

    • Peer Reviewed / Open Access / Int'l Joint Research

URL: 

Published: 2018-12-17  

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