Establishment of objective evaluation system for chronic fatigue syndrome using human peripheral blood induced microglia-like cells

2018 Fiscal Year Final Research Report

• Project/Area Number: 17K19915
• Research Category: Grant-in-Aid for Challenging Research (Exploratory)
• Allocation Type: Multi-year Fund
• Research Field: Health science and related fields
• Research Institution: Kyushu University
• Principal Investigator: Ohgidani Masahiro 九州大学, 医学研究院, 学術研究員 (60636455)
• Project Period (FY): 2017-06-30 – 2019-03-31
• Keywords: ミクログリア

Outline of Final Research Achievements

The aim of this study was to develop an objective evaluation method for the involvement of microglia in chronic fatigue syndrome using the peripheral blood derived microglia-like cell technology.
In a group of fibromyalgia patients with symptoms similar to those of chronic fatigue syndrome, TNF-α gene expression was significantly increased after ATP stimulation. More interestingly, there was a positive correlation between the severity of anxiety and depression (HAD) and the expression level of the TNF-α gene. These findings suggest that psychiatric symptoms in the patient population may be controlled by microglia-derived TNF-α.

Free Research Field

生物学的精神医学

Academic Significance and Societal Importance of the Research Achievements

これまで関連が指摘されていながらも不明のままであった疾患へのミクログリアの関与がヒトレベルで初めて明らかとなった。
臨床症状との相関からも客観的評価法の開発に役立つ研究成果が得られた。