Material Innovation for the Age of Life Science-Creation of Soft and Wet Materials

2010 Fiscal Year Final Research Report

• Project/Area Number: 18002002
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering; Chemistry
• Research Institution: Hokkaido University
• Principal Investigator: GONG Jian Ping 北海道大学, 大学院・先端生命科学研究院, 教授 (20250417)
• Co-Investigator(Kenkyū-buntansha): KAKUGO Akira 北海道大学, 理学研究院, 准教授 (10374224) ; KUROKAWA Takayuki 北海道大学, 創成研究機構, 特任助教 (40451439) ; FURUKAWA Hidemitsu 山形大学, 理工学研究科, 准教授 (50282827) ; TANAKA Yoshimi 横浜国立大学, 環境情報研究院, 准教授 (10315830)
• Co-Investigator(Renkei-kenkyūsha): YASUDA Kazunori 北海道大学, 医学研究科, 教授 (20166507)
• Project Period (FY): 2006 – 2010
• Keywords: ソフト&ウェットマテリアル / ゲル / 高強度 / 高靭性 / 低摩擦 / 生体材料 / バイオトライボロジー / 人工軟骨 / 細胞外マトリックス / 組織再生誘導基材

Research Abstract

Biological tissues, except for the hard skeleton, mainly consist of soft tissues that contain 50-85wt% of water. Creation of soft and wet materials with a high performance as biological soft tissues is essential to the realization of future welfare society. In this study, by controlling the structure of the polymer hydrogels, we have successfully developed various kinds of soft and wet materials having a high toughness and high performance comparable to soft biological tissue. These materials can be applied as alternative materials for soft biological tissues, such as cartilages, tendons, and blood vessels.

Research Products

• [Journal Article] Lamellar Bilayers as Reversible Sacrificial Bonds To Toughen Hydrogel: Hysteresis, Self-Recovery, Fatigue Resistance, and Crack Blunting (2011)
  • Author(s): MA Haque, T Kurokawa, G Kamita, JP Gong
  • Journal Title: Macromolecules Volume: 44 Pages: 8916-8924
  • Peer Reviewed
• [Journal Article] Effect of Hyaluronan Solution on Dynamic Friction of PVA Gel Sliding on Weakly Adhesive Glass Substrate (2011)
  • Author(s): Y Nakano, T Kurokawa, M Du, J Liu, T Tominaga, Y Osada, JP Gong
  • Journal Title: Macromolecules Volume: 44 Pages: 8908-8915
  • Peer Reviewed
• [Journal Article] Microgel-Reinforced Hydrogel Films with High Mechanical Strength and Their Visible Meso-Scale Fracture Structure (2011)
  • Author(s): J Hu, K Hiwatashi, T Kurokawa, SM Liang, ZL Wu, JP Gong
  • Journal Title: Macromolecules Volume: 44 Pages: 7775-7781
  • Peer Reviewed
• [Journal Article] Robust Bonding and One-step Facile Synthesis of Tough Hydrogels with Desirable Shape by Virtue of the Double Network Structure (2011)
  • Author(s): J Saito, H Furukawa, T Kurokawa, R Kuwabara, S Kuroda, J Hu, Y Tanaka, JP Gong, N Kitamura, K Yasuda
  • Journal Title: Polymer Chemistry Volume: 2 Pages: 575-580
  • Peer Reviewed
• [Journal Article] Strain-Induced Molecular Reorientation and Birefringence Reversion of A Robust, Anisotropic Double-Network Hydrogel (2011)
  • Author(s): ZL Wu, D Sawada, T Kurokawa, A Kakugo, W Yang, H Furukawa, JP Gong
  • Journal Title: Macromolecules Volume: 44 Pages: 3542-3547
  • Peer Reviewed
• [Journal Article] Direct Observation on the Surface Fracture of Ultrathin Film Double-Network Hydrogels (2011)
  • Author(s): S Liang, ZL Wu, J Hu, T Kurokawa, QM Yu, JP Gong
  • Journal Title: Macromolecules Volume: 44 Pages: 3016-3020
  • Peer Reviewed
• [Journal Article] Unidirectional alignment of lamellar bilayer in hydrogel: one-dimensional swelling, anisotropic modulus, and stress/strain tunable structural color (2010)
  • Author(s): MA Haque, G Kamita, T Kurokawa, K Tsujii, and JP Gong
  • Journal Title: Advanced Materials Volume: 22 Pages: 5110-5114
  • Peer Reviewed
• [Journal Article] Dual Network Formation in Polyelectrolyte Hydrogel via Viscoelastic Phase Separation: Role of Ionic Strength and Polymerization Kinetics (2010)
  • Author(s): ZL Wu, T Kurokawa, S Liang, JP Gong
  • Journal Title: Macromolecules Volume: 43 Pages: 8203-8208
  • Peer Reviewed
• [Journal Article] Hydrogels with cylindrically symmetric structure at macroscopic scale by self-assembly of semi-rigid polyion complex (2010)
  • Author(s): ZL Wu, T Kurokawa, S Liang, H Furukawa, and JP Gong
  • Journal Title: J. Am. Chem. Soc. Volume: 132 Pages: 10064-10069
  • Peer Reviewed
• [Journal Article] Why are double network hydrogels so tough? (2010)
  • Author(s): JP Gong
  • Journal Title: Soft Matter. Volume: 6 Pages: 2583-2590
  • Peer Reviewed
• [Journal Article] Formation of well-oriented microtubules with preferential polarity in a confined space under a temperature gradient (2009)
  • Author(s): A Kakugo, Y Tamura, K Shikinaka, M Yoshida, R Kawamura, H Furukawa, Y Osada, JP Gong
  • Journal Title: J. Am. Chem. Soc. Volume: 131 Pages: 18089-18095
  • Peer Reviewed
• [Journal Article] Mesoscopic Network Structure of a Semi-Rigid Polyion Complex Nested in a Polycationic Hydrogel (2009)
  • Author(s): ZL Wu, H Furukawa, W Yang, JP Gong
  • Journal Title: Advanced Materials Volume: 21 Pages: 4696-4700
  • Peer Reviewed
• [Journal Article] First Observation of Stick-Slip Instability in Tearing of Poly(vinyl alcohol) Gel Sheets (2009)
  • Author(s): Y Tanaka, H Abe, T Kurokawa, H Furukawa, JP Gong
  • Journal Title: Macromolecules Volume: 42 Pages: 5425-5426
  • Peer Reviewed
• [Journal Article] Direct Observation of Damage Zone around Crack Tips in Double-Network Gels (2009)
  • Author(s): QM Yu, Y Tanaka, H Furukawa, T Kurokawa, JP Gong
  • Journal Title: Macromolecules Volume: 42 Pages: 3852-3855
  • Peer Reviewed
• [Journal Article] A novel double-network hydrogel induces spontaneous articular cartilage regeneration in vivo in a large osteochondral defect (2009)
  • Author(s): K Yasuda, N Kitamura, JP Gong, K Arakaki, HJ Kwon, S Onodera, YM Chen, T Kurokawa, F Kanaya, Y Ohmiya, and Y Osada
  • Journal Title: Macromolecular Biosci. Volume: 9 Pages: 307-316
  • Peer Reviewed
• [Journal Article] True Chemical Structure of Double Network Hydrogels (2009)
  • Author(s): T Nakajima, H Furukawa, Y Tanaka, T Kurokawa, Y Osada, JP Gong
  • Journal Title: Macromolecules Volume: 42 Pages: 2184-2189
  • Peer Reviewed
• [Journal Article] Highly extensible double-network gels with self-assembling anisotropic structure (2008)
  • Author(s): W Yang, H Furukawa, and JP Gong
  • Journal Title: Advanced Materials Volume: 20 Pages: 4499-4503
  • Peer Reviewed
• [Journal Article] Tear Velocity Dependence of High-Strength Double Network Gels in Comparison with Fast and Slow Relaxation Modes Observed by Scanning Microscopic Light Scattering (2008)
  • Author(s): H Furukawa, R Kuwabara, Y Tanaka, T Kurokawa, YH Na, Y Osada, JP Gong
  • Journal Title: Macromolecules Volume: 41 Pages: 7173-7178
  • Peer Reviewed
• [Journal Article] Biological Responses of Novel High-toughness Double Network Hydrogels in Muscle and the Subcutaneous Tissues (2008)
  • Author(s): Y Tanabe, K Yasuda, C Azuma, H Taniguro, S Onodera, A Suzuki, YM Chen, JP Gong, Y Osada
  • Journal Title: J Materials Science: Materials in Medicine Volume: 19 Pages: 1379-1387
  • Peer Reviewed
• [Journal Article] Importance of Entanglement between First and Second Components in High-Strength Double Network Gels (2007)
  • Author(s): M Huang, H Furukawa, Y Tanaka, T Nakajima, Y Osada, JP Gong
  • Journal Title: Macromolecules Volume: 40 Pages: 6658-6664
  • Peer Reviewed
• [Presentation] Fracture of tough double network hydrogel (2011)
  • Author(s): JP Gong
  • Organizer: Gordon Research Conference on Adhesion Science 2011
  • Place of Presentation: Bates College, Lewiston, Maine, USA
  • Year and Date: 20110724-29
• [Presentation] Play with the Tough Double Network Hydrogels (2010)
  • Author(s): JP Gong
  • Organizer: Macro2010: 43rd IUPAC World Polymer Congress
  • Place of Presentation: Scottish Exhibition & Congress Centre, Glasgow, UK
  • Year and Date: 20100711-16
• [Presentation] Tough hydrogels with a double network structure (2010)
  • Author(s): JP Gong
  • Organizer: 2010 March Meeting of the American Physical Society
  • Place of Presentation: Oregon Convention Center, Portland, OR, USA
  • Year and Date: 20100315-19
• [Presentation] Tough DN gel (2009)
  • Author(s): JP Gong
  • Organizer: 14th International Conference on Deformation, Yield and Fracture of Polymers
  • Place of Presentation: Kerkrade, The Netherlands
  • Year and Date: 20090406-09
• [Presentation] Friction & Lubrication of Gels -Towards its Relevance to Biolubrication (2008)
  • Author(s): JP Gong
  • Organizer: Gordon Conference on Tribology
  • Place of Presentation: Colby College, Waterville, ME, USA
  • Year and Date: 2008-07-07
• [Remarks] NHK教育2012年1月18日 報道関連
• [Remarks] NHK総合2011年8月19日 報道関連
• [Remarks] 北海道医療新聞 2008年12月5日 報道関連
• [Remarks] 共同通信2008年11月27日 報道関連
• [Remarks] Baltimore Sun (USA)2008年3月22日 報道関連
• [Remarks] Discovery News (USA)2008年3月21日 報道関連
• [Remarks] In-Pharma (USA)2008年3月19日 報道関連
• [Remarks] Medical News TODAY(USA)2008年3月12日 報道関連
• [Remarks] 日経産業新聞 2007年10月9日 報道関連
• [Remarks] 北海道新聞 2006年5月24日 報道関連
• [Remarks] LSW研究会シンポジウム2006年3月2日、2007年1月12日、2008年1月11日、2009年1月9日、2010年1月8日、2011年1月7日、2012年1月6日 公開行事
• [Remarks] 高分子基礎講座 2006年6月17日、2007年6月16日、2008年6月21日、2009年6月20日、 2010年6月26日、2011年6月11日 公開行事
• [Remarks] 女子中高生理系進路選択支援「理系応援キャラバン隊」 2006年度～2011年度(17回) 公開行事
• [Remarks] ひらめき☆ときめきサイエンス2007年8月7日、2008年9月23日、2009年9月27日 公開行事
• [Remarks] 第7回化学イノベーションシンポジウム2009年8月8日 公開行事
• [Remarks] 未来高分子教室 2008年10月18日 公開行事
• [Remarks] イノベーション・ジャパン2007-大学見本市 2007年9月12日～14日 公開行事
• [Remarks] 北大 de Night Cafe 2007年4月6日 公開行事
• [Remarks] 〓剣萍 高分子学会高分子学会賞2006年5月 受賞
• [Remarks] 〓剣萍 日本化学会第28回学術賞2011年3月 受賞
• [Remarks] 角五彰 文部科学大臣表彰 若手科学者賞 2012年4月 受賞
• [Remarks] 黒川孝幸 高分子学会高分子研究奨励賞 2010年5月 受賞
• [Remarks]
  • URL: http://altair.sci.hokudai.ac.jp/g2/
• [Patent(Industrial Property Rights)] 相互侵入網目構造ゲルと所定の被着材料とから構成される複合材料、その製造方法及び相互侵入網目構造ゲルを所定の被着材料に接着する方法 (2012)
  • Inventor(s): 王蔚、黒川孝幸、古川英光、〓剣萍
  • Industrial Property Rights Holder: 北海道大学
  • Industrial Property Number: 特許, 特許第4915867号
  • Acquisition Date: 2012-02-03
• [Patent(Industrial Property Rights)] 高分子ゲル及びその製造方法 (2010)
  • Inventor(s): 〓剣萍、黒川孝幸、中島祐、佐藤ひとみ
  • Industrial Property Rights Holder: 北海道大学
  • Industrial Property Number: 特許, 特願 2010-175795
  • Filing Date: 2010-08-04
• [Patent(Industrial Property Rights)] 軟骨細胞再分化誘導用基材およびこれを用いた軟骨細胞の製造方法 (2009)
  • Inventor(s): 〓剣萍、楊晶晶
  • Industrial Property Rights Holder: 北海道大学
  • Industrial Property Number: 特許, 特願 2009-226157
  • Filing Date: 2009-09-30
• [Patent(Industrial Property Rights)] 骨充填型軟骨組織再生誘導材 (2008)
  • Inventor(s): 安田和則、長田義仁、〓剣萍、北村信人
  • Industrial Property Rights Holder: 北海道大学
  • Industrial Property Number: 特許, 特願 2008-217253
  • Filing Date: 2008-08-26
  • Overseas