2009 Fiscal Year Final Research Report
System-level Understanding of Intercellular Interactions
| Project/Area Number |
18016031
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
UEDA Hiroki The Institute of Physical and Chemical Research, システムバイオロジー研究チーム, チームリーダー (20373277)
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| Co-Investigator(Kenkyū-buntansha) |
UKAI Hideki 独立行政法人理化学研究所, システムバイオロジー研究チーム, 研究員 (70391878)
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| Project Period (FY) |
2006 – 2009
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| Keywords | システムバイオロジー / 再構成 / 体内時計 / 細胞間情報伝達 / 一細胞イメージング / シンギュラリティー / 光制御 / 位相制御 |
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| Research Abstract |
Central clock (the suprachiasmatic nucleus ; SCN) of mammal produces robust oscillation even in the presence of internal noise without referring to external time cues. Ueda et al proposed stochastic model of intercellular coupling mechanism, and theoretically indicated that the robustness of central clock is caused by intercellular interaction of clock cells (J.Theor.Biol.(2002) 216, 501-512). In this project, we tried to physically simulate the model by synthesis of intercellular interaction mechanism in peripheral clock cells in order to proof the model.
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[Journal Article] Melanopsin-dependent photo-perturbation reveals desynchronization underlying the singularity of mammalian circadian clocks2007
Author(s)
Ukai, H., Kobayashi, T.J., Nagano, M., Masumoto, K., Sujino, M., Kondo, T., Yagita K., Shigeyoshi, Y., Ueda, H.R.
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Journal Title
Nature Cell Biology 9
Pages: 1327-1334
Peer Reviewed
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[Journal Article] A functional genomics strategy reveals clockwork orange as a transcriptional regulator in the Drosophila circadian clock.2007
Author(s)
Matsumoto, A., Ukai-Tadenuma, M., Yamada, R.G., Houl, J., Uno, D.K., Kasukawa, T., Dauwalder, B., Itoh, T., Takahashi, K., Ueda, R., Hardin, P., Tanimura, T, * Ueda, H.R.
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Journal Title
Genes & Development 21(13)
Pages: 1687-700
Peer Reviewed
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[Journal Article] Feedback repression is required for mammalian circadian clock function2006
Author(s)
Sato, T.K., Yamada, R.G., Ukai, H., Baggs, J.E., Miraglia, L.J., Kobayashi, T.J., Welsh, D.K., Kay, S.A., Ueda, H.R. *, Hogenesch, J.B.
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Journal Title
Nature Genetics 38
Pages: 312-319
Peer Reviewed
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[Journal Article] System-level identification of transcriptional circuits underlying mammalian circadian clocks.2005
Author(s)
Ueda, H.R., Hayashi, S., Chen, W.B., Sano, M., Machida, M., Shigeyoshi, Y., Iino, M., Hashimoto, S.
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Journal Title
Nature Genetics 37(2)
Pages: 187-192
Peer Reviewed
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[Book] 生体の科学2008
Author(s)
Ukai, H., Kobayashi, TJ., Ueda, HR.
Total Pages
2
Publisher
医学書院
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[Book]
Author(s)
上田泰己
Publisher
時間生物学会
