2009 Fiscal Year Final Research Report
Metal-Catalyzed Reaction of Main Group Elements
| Project/Area Number |
18064001
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Science and Engineering
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| Research Institution | Hokkaido University |
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Principal Investigator |
MIYAURA Norio Hokkaido University, 大学院・工学研究科, 教授 (10002049)
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| Project Period (FY) |
2006 – 2009
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| Keywords | ホウ素化学 / 合成化学 / 触媒・化学プロセス / 構造・機能化学 |
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| Research Abstract |
We studied B-C bond-forming reactions including borylation of C-H bonds of arenes and alkenes with iridium catalysts. A novel triolborate salts were developed for catalyzed cross-coupling or addition reactions. We developed new bidentate chiral phosphoramidites (Me-BIPAM, N-Me-BIPAM). These ligands were found to be effective for rhodium- and ruthenium-catalyzed asymmetric addition reactions of arylboronic acids to α,β-unsaturated carbonyl compounds, aldehydes and imines.
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[Journal Article] Iridium-Catalyzed C-H Borylation of Arenes and Heteroarenes: 1-Chloro-3-iodo-5-(4, 4, 5, 5-tetramethyl-1, 3, 2-dioxabo rolan-2-yl)benzen and 2-(4, 4, 5, 5-Tetramethyl-1, 3, 2- dioxaborolan-2-yl)indole2009
Author(s)
Ishiyama, T., Takagi, J., Nobuta, Y., Miyaura, N.
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Journal Title
Organic Synthesis Vol.11
Pages: 1007-1014
Peer Reviewed
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[Journal Article] 1, 4-Addition of Arylboronic Acids to β-Aryl-α, β-unsaturated Ketones and Esters Catalyzed by Rhodium(I)-Chiraphos Complex for Catalytic Enantioselective Synthesis of Selective Endothelin A Receptor Antagonists2006
Author(s)
Itoh, T.; Mase, T.; Nishikata, T.; Iyama, T.; Tchikawa, H.; Kobayashi, Y.; Yamamoto, Y.; Miyaura, N.
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Journal Title
Tetrahedron 62
Pages: 9610-9621
Peer Reviewed
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[Remarks] 宮浦憲夫文部科学大臣表彰科学技術賞(平成22年4月13日)
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[Remarks] 日本化学会賞(平成20年3月27日)
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[Remarks] 有機合成化学協会賞(平成19年2月22日)
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[Remarks] 山本靖典日本化学会北海道支部奨励賞(平成19年2月6日)
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[Remarks] SYNFACTS 2009, 885 "Enantioselective Ruthenium(II)- catalyzed Aldehydes Arylations"
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[Remarks] SYNFACTS 2009, 650 "Rhodium-Catalyzed Asymmetric 1, 4-Addition of Heteroaryl Triolborates"
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[Remarks] SYNFACTS 2008, 743 "Biaryls via a One-Pot Borylation- Cross-Coupling Sequence Using Pinacolborane"
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