2010 Fiscal Year Final Research Report
Novel Mechanisms of the Regulation of Reproduction by Novel Brain Hormones
| Project/Area Number |
18107002
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphology/Structure
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| Research Institution | Waseda University |
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Principal Investigator |
TSUTSUI Kazuyoshi Waseda University, 教育・総合科学学術院, 教授 (20163842)
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| Co-Investigator(Kenkyū-buntansha) |
MINAKATA Hiroyuki サントリー生物有機科学研究所, 部長研究員 (90150143)
UKENA Kazuyoshi 広島大学, 大学院・総合科学研究科, 准教授 (10304370)
TANAKA Shigeyasu 静岡大学, 創造科学技術大学院, 教授 (90146233)
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| Project Period (FY) |
2006 – 2010
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| Keywords | 視床下部ホルモン / 脳下垂体ホルモン / 発現制御 / シグナル伝達 / 生殖 |
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| Research Abstract |
We discovered a novel avian hypothalamic neuropeptide inhibiting gonadotropin release, named gonadotropin-inhibitory hormone (GnIH). We demonstrated that GnIH acts on gonadotropes and GnRH neurons via GPR147 to inhibit gonadal development and maintenance by decreasing gonadotropin release and synthesis. We further demonstrated that GnIH has an evolutionarily conserved role in controlling reproduction across vertebrate species.
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[Remarks] プレスリリース
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[Remarks] 2009年12月24日読売新聞掲載
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[Remarks] 2008年3月2日読売新聞掲載
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[Remarks] 2008年3月2日YOMIURI ONLINE掲載
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[Remarks] 2007年9月10日asahi.com OPINION(朝日新聞社報)掲載
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