2009 Fiscal Year Final Research Report
Creation of time-resolved thermodynamics and application to elucidation of protein reaction mechanism
| Project/Area Number |
18205002
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
TERAZIMA Masahide Kyoto University, 大学院・理学研究科, 教授 (00188674)
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| Project Period (FY) |
2006 – 2009
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| Keywords | 熱力学 / 時間分解 / タンパク質 / 反応ダイナミクス / 過渡回折格子 / 反応中間体 |
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| Research Abstract |
A new scientific research field "time-resolved thermodynamics" was created so that two important fields, the thermodynamics and the dynamics, are unified. This new technique was applied to researches of reaction mechanism of biological proteins and various thermodynamical properties, i.e., enthalpy, partial molar volume, heat capacity change and so on, have been measured in time domain for the first time. Many spectrally silent dynamics of protein reactions were elucidated and reaction mechanisms in molecular level have been established.
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[Journal Article] Conformational Changes during Apoplastocyanin Folding Observed by Photocleavable Modification and Transient Grating2006
Author(s)
S. Hirota, Y. Fujimoto, J. Choi, N. Baden, N. Katagiri, M. Akiyama, R. Hulsker, M. Ubbink, T. Okajima, T. Takabe, N. Funasaki, Y. Watanabe, M. Terazima
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Journal Title
J. Am. Chem. Soc. 128
Pages: 7551-7558
Peer Reviewed
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