2009 Fiscal Year Final Research Report
Clarification of retrotransposition mechanisms of target-specific LINE
| Project/Area Number |
18207001
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Genetics/Genome dynamics
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
FUJIWARA Haruhiko The University of Tokyo, 大学院・新領域創成科学研究科, 教授 (40183933)
|
|---|
| Project Period (FY) |
2006 – 2009
|
| Keywords | レトロトランスポゾン / 標的特異的LINE / 転移機構 |
|---|
| Research Abstract |
We have studied molecular mechanisms of retrotransposition of non-LTR retrotransposon, so called LINE, which is the most major elements in chromosomes of higher organisms such as human, using target specific LINEs. In this project, we have succeeded in clarifying the mechanisms of how the translation of LINE proteins is regulated, how ribonucleoprotein (RNP) complex of proteins and mRNA of LINEs are constructed, and how the complex approach to the target sequences in chromosomes, which are novel mechanisms peculiar to LINE.
|
-
[Journal Article] Unique functions of the repetitive transcriptome. International Review of Cell and Molecular Biology2012
Author(s)
Schumann, G.G., Elena V.Gogvadze E.V., Osanai-Futahashi, M., Kuroki, A., Munk, C., Fujiwara H., Ivics, Z., Buzdin, A.
-
Journal Title
Former International Review of Cytology in press(掲載確定)
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Mechanisms and applications of sequence-specific non-LTR retrotransposon identified from the insect genome.2010
Author(s)
Fujiwara H., Osanai-Futahashi, M., Kuroki, A.Kawashima, T., Yoshitake, K.
Organizer
Internationa symposium, New silk road : Silkworm genome to sustainable agriculture, Tuskuba Center for Instiutes
Place of Presentation
Tsukuba, Japan.
Year and Date
20101109-20101110
-
-
-
-
-
-
-
-
-
-
