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2008 Fiscal Year Final Research Report

Development of gene carriers based on in vivo and intracellular distribution real-time analysis

Research Project

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Project/Area Number 18209006
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical pharmacy
Research InstitutionKyoto University

Principal Investigator

MITSURU Hashida  Kyoto University, 薬学研究科, 教授 (20135594)

Co-Investigator(Kenkyū-buntansha) FUMIYOSHI Yamashita  京都大学, 薬学研究科, 准教授 (30243041)
SHIGERU Kawakami  京都大学, 薬学研究科, 助教 (20322307)
YURIKO Higuchi  京都大学, 薬学研究科, 研究員 (40402797)
Project Period (FY) 2006 – 2008
Keywordsドラッグデリバリー / 遺伝子治療
Research Abstract

本研究の目的は、in vivoにおいて十分な効果を発現する遺伝子導入ベクター開発に必要な, 生体内および細胞内での遺伝子キャリアの動態をリアルタイムで評価できる実験法を確立し, その評価解析結果に基づいてキャリアを合理的に設計することである。非ウイルス性遺伝子導入キャリアとプラスミドDNAの複合体のin vivoならびに細胞内の動態を解析し、遺伝子発現と動態との関係を明らかにし、細胞内動態とキャリアの安全性の観点からその関係を明らかにした。また、これらの情報を基に遺伝子導入キャリアの設計および開発並びにマウスの肺がんモデルを用いた治療への応用を検討した。

  • Research Products

    (14 results)

All 2009 2008 2007 2006

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (2 results)

  • [Journal Article] Immunostimulatory Characteristics Induced by LinearPolyethyleneimine/plasmid DNA Complexes in Cultured Macrophages2009

    • Author(s)
      Yasunori Saito, Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
    • Journal Title

      Human Gene Therapy 20(2)

      Pages: 137-145

    • Peer Reviewed
  • [Journal Article] Renal press-mediatedtransfection method for plasmid DNAand siRNA to the kidney2008

    • Author(s)
      Hidefumi Mukai, Shigeru Kawakami, Mitsuru Hashida
    • Journal Title

      Biochemical and Biophysical Research Communications 372(3)

      Pages: 383-387

    • Peer Reviewed
  • [Journal Article] Pharmacokinetic considerations reganding non-viral cancer gene theraphy2008

    • Author(s)
      Makiya Nishikawa, Yoshinobu Takakura,Mitsuru Hashida
    • Journal Title

      Cancer Science 95(5)

      Pages: 856-862

    • Peer Reviewed
  • [Journal Article] Insertion of nuclear factor-κB binding sequence into plasmid DNA for increased transgene expression in colon carcinomacells2008

    • Author(s)
      Oranuch Thanaketpaisarn, Makiya Nishikawa, Takayuki Okabe, Fumiyoshi Yamashita, Mitsuru Hashida
    • Journal Title

      Journal of Biotechnology 133(1)

      Pages: 36-41

    • Peer Reviewed
  • [Journal Article] Efficient protection by cationizedcatalase against H2O2 injury in primary cultured alveolar epithelial cells2007

    • Author(s)
      Takayuki Nemoto, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
    • Journal Title

      Journal of Controlled Release 121(1-2)

      Pages: 74-80

    • Peer Reviewed
  • [Journal Article] Hepatocyte-selective gene transfer by galactosylated protein/linear polyethylenimine/plasmid DNA complexes in mice2007

    • Author(s)
      Miyuki Hohokabe, Yuriko Higuchi, Hidefumi Mukai, Shigeru Kawakami, Mitsuru Hashida
    • Journal Title

      Journal of Biome dical Nanotechnology 3(3)

      Pages: 277-284

    • Peer Reviewed
  • [Journal Article] The potential role of fucosylated cationic liposome/NFkB decoy complexesin the treatment of cytokine-related liver disease2007

    • Author(s)
      Yuriko Higuchi, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
    • Journal Title

      Biomaterials 28(3)

      Pages: 532-539

    • Peer Reviewed
  • [Journal Article] Small interfering RNA delivery to the liver by intravenous administration of galactosylated cationicliposomes in mice2007

    • Author(s)
      Ayumi Sato, Motoki Takagi, Akira Shimamoto, Shigeru Kawakami, Mitsuru Hashida
    • Journal Title

      Biomaterials 28(7)

      Pages: 1434-1442

    • Peer Reviewed
  • [Journal Article] Inhibition of peritoneal dissemination of tumor cells bysingle dosing of phosphodiester CpGoligonucleotide/cationic liposome complex2006

    • Author(s)
      Yukari Kuramoto, Makiya Nishikawa, Kenji Hyoudou, Fumiyoshi Yamashita, Mitsuru Hashida
    • Journal Title

      Journal of Controlled Release 115(2)

      Pages: 226-233

    • Peer Reviewed
  • [Journal Article] Novel PEG-matrix metalloproteinase-2 cleavable peptide-lipidconntaining galactosylated liposomes for hepatocellular carcinoma-selec tive targeting2006

    • Author(s)
      Takeshi Terada, Mieko Iwai, Shigeru Kawakami, Fumiyoshi Yamashita, Mitsuru Hashida
    • Journal Title

      Journal of Controlled Release 111(3)

      Pages: 333-342

    • Peer Reviewed
  • [Journal Article] Evaluation of proinflammatory cytokine production induced by linear and branched polyethylenimine/plasmid DNA complexes in mice2006

    • Author(s)
      Shigeru Kawakami, Yoshitaka Ito, Pensri Charoensit, Fumiyoshi Yamashita,Mitsuru Hashida
    • Journal Title

      Journal of Pharmacology and Experimental Therapeutics 317(3)

      Pages: 1382-1390

    • Peer Reviewed
  • [Journal Article] Analysis of the molecular interaction of glycosylated prpteins with rabbit liver asialoglycoprotein receptors using surface plasmon resonance spectroscopy2006

    • Author(s)
      Takeshi Terada, Makiya Nishikawa, Fumiyoshi Yamashita, Mitsuru Hashida
    • Journal Title

      Journal of Pharmaceutical and Biomedical Analysis 41

      Pages: 966-972

    • Peer Reviewed
  • [Presentation] Inhalation of Dexamethasone Palmitate Encapsulated Mannosylated Liposomes Efficiently Ameliorates LPS-Induced Lung Inflammation in Rats2008

    • Author(s)
      Wassana Wijagkanalan, Shigeru Kawakami, Mariko Kuroda, Hitoshi Sasaki, Fumiyoshi Yamashita, Mitsuru Hashida
    • Organizer
      第11回国際リポソーム研究会議
    • Place of Presentation
      横浜
    • Year and Date
      2008-07-19
  • [Presentation] Evaluation of proinflammatory cytokine production inducedby siRNA/polyethylenimine complexes2008

    • Author(s)
      Pensri Charoensit、川上茂、山下富義、橋田充
    • Organizer
      第24回日本DDS学会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-29

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Published: 2010-06-10   Modified: 2016-04-21  

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