Interactive Radiotherapy

2008 Fiscal Year Final Research Report

• Project/Area Number: 18209039
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Radiation science
• Research Institution: Hokkaido University
• Principal Investigator: SHIRATO Hiroki Hokkaido University, 大学院・医学研究科, 教授 (20187537)
• Co-Investigator(Kenkyū-buntansha): HONMA Sato 北海道大学, 大学院・医学研究科, 教授 (20142713) ; TAMAKI Nagara 北海道大学, 大学院・医学研究科, 教授 (30171888) ; KUGE Yuji 北海道大学, 大学院・医学研究科, 教授 (70321958) ; DATE Hiroyuki 北海道大学, 大学院・保健科学研究院, 教授 (10197600) ; KIYANAGI Yoshiaki 北海道大学, 大学院・工学研究科, 教授 (80002202) ; HATAKEYAMA Masanori 北海道大学, 遺伝子病制御研究所, 教授 (40189551) ; KANEKO Junichi 北海道大学, 大学院・工学研究科, 准教授 (90333624) ; MIZUTA Masahiro 北海道大学, 情報基盤センター, 教授 (70174026) ; INUBUSHI Masayuki (独)放射線医学総合研究所, 分子イメージング研究センター, 研究員 (70399830) ; TADANO Shigeru 北海道大学, 大学院・工学研究科, 教授 (50175444) ; TAMURA Mamoru 北海道大学, 電子科学研究所, 教授 (80089888) ; HAYAKAWA Kazushige 北里大学, 医学部, 教授 (70114189) ; MATSUNAGA Naofumi 山口大学, 医学部, 教授 (40157334) ; ISHIKAWA Masayori 北海道大学, 大学院・医学研究科, 准教授 (80314772) ; AOYAMA Hidefumi 北海道大学, 大学院・医学研究科, 准教授 (80360915) ; SAKUHARA Yusuke 北海道大学, 大学病院, 助教 (40374459) ; ONIMARU Rikiya 北海道大学, 大学病院, 助教 (80374461) ; ABO Daisuke 北海道大学, 大学病院, 助教 (30399844) ; OITA Masataka 北海道大学, 大学病院, 特任助手 (10380023) ; KAMISHIMA Tamotsu 北海道大学, 大学病院, 講師 (10399868) ; TERAE Satoshi 北海道大学, 大学病院, 准教授 (40240634) ; KUDO Kohsuke 岩手医科大学, 先端医療研究センター, 講師 (10374232) ; ONODERA Yuya 北海道大学, 大学病院, 講師 (10272064) ; OMATSU Tokuhiko 北海道大学, 大学病院, 助教 (90374280) ; SHIMIZU Shinichi 北海道大学, 大学院・医学研究科, 特任講師 (50463724) ; NISHIMURA Takashi 北海道大学, 遺伝子病制御研究所, 教授 (30143001) ; SUZUKI Ryusuke 北海道大学, 大学病院, 特任講師 (00400052) ; GERARD Bengua 北海道大学, 大学病院, 特任助教 (50402954)
• Project Period (FY): 2006 – 2008
• Keywords: 量子線シミュレーション / 電子線トラック解析 / モンテカルロ法 / 放射線治療 / 炎症性発癌 / プラスチック検出器 / 体幹部定位放射線照射 / 非線形最適化

Research Abstract

いままでの先端放射線医療に欠けていた医療機器と患者のinteractionを取り入れた放射線治療を可能にする。臓器の動き・腫瘍の照射による縮小・免疫反応などは、線量と時間に関して非線形であり、システムとしての癌・臓器の反応という概念を加えることが必要であることが示唆された。生体の相互作用を追求していく過程で、動体追跡技術は先端医療のみならず、基礎生命科学でも重要な役割を果たすことがわかった。

Research Products

• [Journal Article] Difference in the Tracer Delay-Induced Effect among Deconvolution Algorithms in CT Perfusion Analysis: Quantitative Evaluation by using Digital Phantoms. (2009)
  • Author(s): Kudo K, Sasaki M, Ogasawara K, Terae S, Ehara S, Shirato H
  • Journal Title: Radiology 251(1) Pages: 241-249
  • Peer Reviewed
• [Journal Article] Power Doppler ultrasound of rheumatoid synovitis: quantification of vascular signal and analysis of interobserver variability. (2009)
  • Author(s): Kamishima T, Tanimura K, Henmi M, Narita A, Sakamoto F, Terae S, Shirato H
  • Journal Title: Skeletal Radiol 38 Pages: 467-472
  • Peer Reviewed
• [Journal Article] Computational Simulation of Three-dimensional Tumor Geometry during Radiotherapy. (2009)
  • Author(s): Takao S, Tadano S, Hiroshi H, Shirato H
  • Journal Title: Proceedings of 13th International Conference on Biomedical Engineering. 23(CDROM) Pages: 2083-2087
  • Peer Reviewed
• [Journal Article] Nanometer site analysis of electron tracks and dose localization in bio-cells exposed to X-ray irradiation. (2009)
  • Author(s): Date H, Yoshii Y, Sutherland KL
  • Journal Title: Nucl. Instr. and Meth. B 267 Pages: 1135-1138
  • Peer Reviewed
• [Journal Article] A feasibility study of novel plastic scintillation dosimetry with pulse counting mode. (2009)
  • Author(s): Ishikawa M, Bengua G, Sutherland K, Hiratsuka J, Katoh N, Shimizu S, Aoyama H, Fujita K, Yamazaki R, Horita K, Shirato H
  • Journal Title: Physics in Medicine and Biology. 54 Pages: 2079-2092
  • Peer Reviewed
• [Journal Article] Histopathologic consideration of fiducial gold markers inserted for real-time tumor-tracking radiotherapy against lung cancer. (2008)
  • Author(s): Imura M, Yamazaki K, Kubota KC, Itoh T, Onimaru R, Cho Y, Hida Y, Kaga K, Onodera Y, Ogura S, Dosaka-Akita H, Shirato H, Nishimura M
  • Journal Title: Int J Radiat Oncol Biol Phys. 1;70(2) Pages: 382-384
  • Peer Reviewed
• [Journal Article] Steep dose-response relationship for stage I non-small-cell lung cancer using hypofractionated high-dose irradiation by real-time tumor-tracking radiotherapy. (2008)
  • Author(s): Onimaru R, Fujino M, Yamazaki K, Onodera Y, Taguchi H, Katoh N, Hommura F, Oizumi S, Nishimura M, Shirato H
  • Journal Title: Int J Rad Oncol Biol Phys 70(2) Pages: 374-381
  • Peer Reviewed
• [Journal Article] Isolation of a distinct class of gain-of-function SHP-2 muntants with oncogenic RAS-like transforming activity from solid tumors. (2008)
  • Author(s): Miyamoto D, Miyamoto M, Takahashi A, Yomogita Y, Higashi H, Kondo S, Hatakeyama M
  • Journal Title: Oncogene 27(25) Pages: 3508-3815
  • Peer Reviewed
• [Journal Article] Splenic peliosis mimicking a solid tumor: findings in multimodalities. (2008)
  • Author(s): Abo D, Terae S, Fukasawa Y, Seki H, Hasegawa Y, Sakuhara Y, Shimizu T, Shirato H
  • Journal Title: J Comput Assist Tomogr. 32 Pages: 890-892
  • Peer Reviewed
• [Journal Article] Evaluation of the vascular supply to regions of the pancreas on CT during arteriography. (2008)
  • Author(s): Sakuhara Y, Kodama Y, Abo D, Hasegawa Y, Shimizu T, Omatsu T, Kamishima T, Onodera Y, Terae S, Shirato H
  • Journal Title: Abdom Imaging 56 Pages: 563-570
  • Peer Reviewed
• [Journal Article] 11C-methionine, not 18F-FDG or 18F-FLT can differentiate tumors from granulomas in experimental rat models. (2008)
  • Author(s): Zhao S, Kuge Y, Kohanawa M, Takahashi T, Zhao Y, Yi M, Kanegae K, Seki KI, Tamaki N
  • Journal Title: J Nucl Med 49(1) Pages: 135-141
  • Peer Reviewed
• [Journal Article] EGFR genetic heterogeneity of nonsmall cell lung cancers contributing to acquired gefitinib resistance. (2008)
  • Author(s): Jiang SX, Yamashita K, Yamamoto M, Piao CJ, Umezawa A, Saegusa M, Yoshida T, Katagiri M, Masuda N, Hayakawa K, Okayasu I
  • Journal Title: Int J Cancer 123(11) Pages: 2480-2486
  • Peer Reviewed
• [Journal Article] Intercepting radiotherapy using a real-time tumor-tracking radiotherapy system for highly selected patients with hepatocellular carcinoma unresectable with other modalities. (2007)
  • Author(s): Taguchi H, Sakuhara Y, Hige S, Kitamura K, Osaka Y, Abo D, Uchida D, Sawada A, Kamiyama T, Shimizu T, Shirato H, Miyasaka K
  • Journal Title: Int J Rad Oncol Biol Phys 69(2) Pages: 376-380
  • Peer Reviewed
• [Journal Article] Organ motion in image-guided radiotherapy: lessons from real-time tumor-tracking radiotherapy. (2007)
  • Author(s): Shirato H, Shimizu S, Kitamura K, Onimaru R
  • Journal Title: Int J ClinOncol 12(1) Pages: 8-16
  • Peer Reviewed
• [Journal Article] Separate oscillating cell groups in mouse suprachiasmatic nucleus couple photoperiodically to the onset and end of daily activity. (2007)
  • Author(s): Inagaki N, Honma S, Ono D, Tanahashi Y, Honma K
  • Journal Title: Proc. Natl. Acad. Sci. U.S.A. 104 Pages: 7664-7669
  • Peer Reviewed
• [Journal Article] Ionization and excitation processes of electrons in liquid water Nucl. (2007)
  • Author(s): Date H, Sutherland K L, Hasegawa H Shimozuma M
  • Journal Title: Instr. and Meth. B265 Pages: 515-520
  • Peer Reviewed
• [Journal Article] Functional Data Analysis and Its Application. (2007)
  • Author(s): Mizuta M, Kato J
  • Journal Title: Lecture Notes in Artificial Intelligence Subseries of Lecture Notes in Computer Science 4481 Pages: 228-235
  • Peer Reviewed
• [Journal Article] Phase I trial of neoadjuvant preoperative chemotherapy with S-1 and Irinotecan plus radiation in patients with locally advanced rectal cancer. (2007)
  • Author(s): Sato T, Kokuba Y, Koizumi W, Hayakawa K, Okayasu I, Watanabe M
  • Journal Title: Int J Radiat Oncol Biol Phys 69(5) Pages: 1442-1447
  • Peer Reviewed
• [Journal Article] Discrete functional data analysis. (2006)
  • Author(s): Mizuta, M
  • Journal Title: Proc. in Computational Statistics Pages: 361-369
  • Peer Reviewed
• [Journal Article] Stereotactic radiosurgery plus whole-brain radiation therapy vs stereotactic radiosurgery alone for treatment of brain metastases: a randomized controlled trial. (2006)
  • Author(s): Aoyama H, Shirato H, Tago M, Nakagawa K, Toyoda T, Hatano K, Kenjyo M, Oya N, Hirota S, Shioura H, Kunieda E, Inomata T, Hayakawa K, Katoh N, Kobashi G
  • Journal Title: JAMA 295(21) Pages: 2483-2491
  • Peer Reviewed
• [Remarks] 業績紹介
  • URL: http://rad.med.hokudai.ac.jp
• [Patent(Industrial Property Rights)] 動的腫瘍の放射線治療装置および動的腫瘍の放射線治療プログラム (2008)
  • Inventor(s): 金子純一, 他
  • Industrial Property Rights Holder: 北海道大学
  • Industrial Property Number: 特許・特願2007-041373PCT/JP2008/052944
  • Filing Date: 2008-02-20