Clinical application of pain therapy based on basic studies on human pain perception.

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18209048
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Anesthesiology/Resuscitation studies
• Research Institution: National Institute for Physiological Sciences
• Principal Investigator: KAKIGI Ryusuke National Institute for Physiological Sciences, 統合生理研究系, 教授 (10145196)
• Project Period (FY): 2006 – 2009
• Keywords: 疼痛治療学

Research Abstract

種々の非侵襲的計測法を用いてヒトの脳内痛覚認知機構を明らかにすること、及び、基礎的研究によって得られた知見を元にして除痛治療を行う事、すなわちpain clinicにおけるEvidence-Based Medicineの施行が主要研究目的である。

Research Products

• [Journal Article] Centrifugal modulation of human LEP components to a task-relevant noxious stimulation triggering voluntary movement (2009)
  • Author(s): Nakata H, Sakamoto K, Honda Y, Mochizuki H, Hoshiyama M & Kakigi R
  • Journal Title: Neuroimage 45 Pages: 129-142
  • Peer Reviewed
• [Journal Article] Pain-related evoked potentials are modulated across the cardiac cycle (2008)
  • Author(s): Edwards L, Inui K, Ring C, Wang X, Kakigi R
  • Journal Title: Pain 137(3) Pages: 488-494
  • Peer Reviewed
• [Journal Article] Itching- related somatosensory evoked potentials (2008)
  • Author(s): Mochizuki H, Inui K, Yamashiro K, Ootsuru N, Kakigi R
  • Journal Title: Pain 138(3) Pages: 598-603
  • Peer Reviewed
• [Journal Article] Evoked magnetic fields following noxious laser stimulation of the thigh in humans (2008)
  • Author(s): Nakata H, Tamura Y, Sakamoto K, Akatsuka K, Hirai M, Inui K, Hoshiyama M, Saitoh Y, Yamamoto T, Katayama Y & Kakigi R
  • Journal Title: Neuroimage 42(2) Pages: 858-868
  • Peer Reviewed
• [Journal Article] Inner experience of pain : imagination of pain while viewing images showing painful events forms subjective pain representation in human brain (2007)
  • Author(s): Ogino Y, Nemoto H, Inui K, Saito S, Kakigi R, Goto F
  • Journal Title: Cerebral Cortex 17(5) Pages: 1139-1146
  • Peer Reviewed
• [Presentation] Brain processing of the signals ascending through C and A-delta fibers : fMRI study (2008)
  • Author(s): Kakigi R
  • Organizer: The 14th ASEAN Association of Radiology Meeting
  • Place of Presentation: Hanoi, Vietnam
  • Year and Date: 20080921-23
• [Presentation] Painful brain. Keynote lecture (2006)
  • Author(s): Kakigi R
  • Organizer: 17th International Society for Brain Electromagnetic Topography(ISBET2006)
  • Place of Presentation: Chieti, Italy
  • Year and Date: 20060927-30
• [Presentation] Update on evoked potentials and fields. Breakfast session (2006)
  • Author(s): Kakigi R
  • Organizer: The 28th International Congress of Clinical Neurophysiology
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 20060910-14
• [Presentation] New aspects on the function of spinal cord(spinothalamic tract)related to pain. Symposium "Pain syndrome" (2006)
  • Author(s): Kakigi R
  • Organizer: The 28th International Congress of Clinical Neurophysiology
  • Place of Presentation: Edinburgh, UK
  • Year and Date: 20060910-14
• [Presentation] Somatosensory systems and Pain Investigation of pain perception following C-fiber stimulation in humans (2006)
  • Author(s): Kakigi R
  • Organizer: The 15th International Conference on Biomagnetism(BIOMAG 2006)
  • Place of Presentation: Vancouver, Canada
  • Year and Date: 20060820-26
• [Book] Magnetoencephalography in assessment of pain in humans. In "Encyclopedic Reference of Pain" (2007)
  • Author(s): Kakigi R
  • Total Pages: 1090-1094
  • Publisher: Ed. Bilic M, Springer, Berlin
• [Book] Pain evoked potential and magnetic fields in relation to sleep and pain. In "Sleep and Pain" (2007)
  • Author(s): Kakigi R, Wang X, Inui K, Qiu Y
  • Total Pages: 175-187
  • Publisher: Eds. Lavigne G, Choiniere M, Sessle BJ, Soja P. IASP press, Seatle
• [Book] Cortical processing of noxious information in humans : a magnetoencephalographic study. Clin Neurophysiol. Supplement 59 (2006)
  • Author(s): Inui K, Wang X, Qiu Y, Tsuji T, Nakata H, Kakigi R
  • Total Pages: 127-133
  • Publisher: Eds. Tsuji S, Barber C, Tobimatsu S, Elsevier, Amsterdam