Neural basis of memory errors

2008 Fiscal Year Final Research Report

• Project/Area Number: 18300087
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cognitive science
• Research Institution: Tohoku University
• Principal Investigator: FUJII Toshikatsu Tohoku University, 大学院・医学系研究科, 准教授 (70271913)
• Co-Investigator(Renkei-kenkyūsha): MORI Etsuro 東北大学, 大学院・医学系研究科, 教授 (30368477) ; SUZUKI Maki 東北大学, サイクロトロン・ラジオアイソトープセンター, 講師 (80422145) ; MUGIKURA Shunji 東北大学, 大学病院, 助教 (20375017) ; OKUDA Jiro 京都産業大学, コンピュ-タ理工学部, 准教授 (80384725)
• Project Period (FY): 2006 – 2008
• Keywords: 脳認知科学

Research Abstract

ヒトの記憶については心理学的・神経科学的な研究が数多く行われてきていたが、記憶の間違い-つまり、記憶として想起はできるものの内容が正確ではない場合-のメカニズムについては不明な点が多い。本研究ではヒトの脳活動を間接的に測定することができる脳機能画像法と、脳損傷患者を対象とした神経心理学的研究によって、ヒトの脳でどのように誤った記憶情報が表象されるのかを検討した。記憶を司る内側側頭葉に対して、記憶を制御する前頭前野が影響を与えていることや、内側側頭葉と感覚情報を処理する感覚皮質の関連が明らかとなった。

Research Products

• [Journal Article] Neural correlates of true memory, false memory, and deception (2008)
  • Author(s): Abe N, Okuda J, Suzuki M, Sasaki H, Matsuda T, Mori E, Tsukada M, Fujii T
  • Journal Title: Cerebral Cortex 18 Pages: 2811-2819
  • Peer Reviewed
• [Journal Article] Reactivation of medial temporal lobe and occipital lobe during the retrieval of color information : a positron emission tomography study (2007)
  • Author(s): Ueno A, Abe N, Suzuki M, Hirayama K, Mori E, Tashiro M, Itoh M, Fujii T
  • Journal Title: Neuroimage 34 Pages: 1292-1298
  • Peer Reviewed
• [Journal Article] Deceiving others : distinct neural responses of the prefrontal cortex and amygdala in simple fabrication and deception with social interactions (2007)
  • Author(s): Abe N, Suzuki M, Mori E, Itoh M, Fujii T
  • Journal Title: Journal of Cognitive Neuroscience 19 Pages: 287-295
  • Peer Reviewed
• [Journal Article] Differential involvement of regions of rostral prefrontal cortex (Brodmann area 10) in time-and event-based prospective memory (2007)
  • Author(s): Okuda J, Fujii T, Ohtake H, Tsukiura T, Yamadori A, Frith CD, Burgess PW
  • Journal Title: International Journal of Psychophysiology 64 Pages: 233-246
  • Peer Reviewed
• [Journal Article] Selective impairment in the retrieval of family relationships in person identification : a case study of delusional misidentification (2007)
  • Author(s): Abe N, Ishii H, Fujii T, Ueno A, Lee E, Ishioka T, Mori E
  • Journal Title: Neuropsychologia 45 Pages: 2902-2909
  • Peer Reviewed
• [Journal Article] Pure word deafness and pure anarthria in a patient with frontotemporal dementia (2007)
  • Author(s): Iizuka O, Suzuki K, Endo K, Fujii T, Mori E
  • Journal Title: European Journal of Neurology 14 Pages: 473-475
  • Peer Reviewed
• [Journal Article] Dissociable roles of prefrontal and anterior cingulate cortices in deception (2006)
  • Author(s): Abe N, Suzuki M, Tsukiura T, Mori E, Yamaguchi K, Itoh M, Fujii T
  • Journal Title: Cerebral Cortex 16 Pages: 192-199
  • Peer Reviewed
• [Journal Article] Dissociable roles of the bilateral anterior temporal lobe in face-name associations : an event-related fMRI study (2006)
  • Author(s): Tsukiura T, Mochizuki-Kawai H, Fujii T
  • Journal Title: Neuroimage 30 Pages: 617-626
  • Peer Reviewed
• [Presentation] Activity in the medial temporal lobes predicts realization of intentions for future actions (2008)
  • Author(s): Okuda J, Abe N, Suzuki M, Fujii T
  • Organizer: 14th Annual meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 20080615-19
• [Presentation] Neural mechanisms for the retrieval of time duration of past events (2008)
  • Author(s): Suzuki M, Abe N, Mugikura S, Ueno A, Shigemune Y, Shoki Takahashi S, Fujii T
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20080412-15
• [Presentation] Reactivation of medial temporal lobe and area MT/V5 during the retrieval of motion information : a PET study (2008)
  • Author(s): Ueno A, Abe N, Suzuki M, Shigemune Y, Hirayama K, Mori E, Tashiro M, Itoh M, Fujii T
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20080412-15
• [Presentation] Effects of emotion and reward motivation on neural activity associated with episodic memory encoding : a PET study (2008)
  • Author(s): Shigemune Y, Abe N, Suzuki M, Ueno A, Mori E, Tashiro M, Itoh M, Fujii T
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20080412-15
• [Presentation] Recollection failure increases false recognition in patients with Alzheimer's disease (2008)
  • Author(s): Abe N, Fujii T, Nishio Y, Iizuka O, Kanno S, Kikuchi H, Takagi M, Hiraoka K, Yamasaki H, Hirayama K, Choi H, Mori E
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20080412-15
• [Presentation] Roles of the medial frontal cortex and hippocampus in memory-guided future planning (2008)
  • Author(s): Okuda J, Watanabe M, Fujii T, Suzuki M, Abe N, Tsukada M
  • Organizer: 15^<th> Cognitive Neuroscience Society Annual Meeting
  • Place of Presentation: San Francisco, USA
  • Year and Date: 20080412-15
• [Presentation] The neural network for temporal order memory retrieval : evidence from lesion and PET studies (2007)
  • Author(s): Suzuki M, Hashimoto R, Hirayama K, Abe N, Ueno A, Tashiro M, Mori E, Itoh M, Fujii T
  • Organizer: International Neuropsychological Society Mid-Year Meeting 2007
  • Place of Presentation: Bilbao, Spain
  • Year and Date: 20070704-08
• [Presentation] A peculiar form of delusional misidentification : a neuropsychological case study providing a window on person identification (2007)
  • Author(s): Abe N, Ishii H, Fujii T, Ueno A, Lee EJ, Ishioka T, Mori E
  • Organizer: International Neuropsychological Society Mid-Year Meeting 2007
  • Place of Presentation: Bilbao, Spain
  • Year and Date: 20070704-08
• [Presentation] Brain mechanisms underlying dissociative retrograde amnesia : an fMRI study (2007)
  • Author(s): Kikuchi H, Fujii T, Abe N, Suzuki M, Mugikura S, Takahashi S, Mori E
  • Organizer: International Neuropsychological Society Mid-Year Meeting 2007
  • Place of Presentation: Bilbao, Spain
  • Year and Date: 20070704-08
• [Presentation] Distinct medial temporal lobe activations associated with the retrieval of different types of information attached with items : an fMRI study (2006)
  • Author(s): Fujii T, Suzuki M, Abe N, Mugikura S, Ueno A, Mori E, Takahashi S
  • Organizer: The 4^<th> International Conference on Memory
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20060716-21
• [Presentation] Neural basis of the retrieval of temporal order memory of experienced events : A PET study (2006)
  • Author(s): Suzuki M, Abe N, Ueno A, Tashiro M, Mori E, Itoh M, Fujii T
  • Organizer: The 4^<th> International Conference on Memory
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20060716-21
• [Presentation] Brain activities associated with false memory and deception : an fMRI investigation (2006)
  • Author(s): Abe N, Okuda J, Suzuki M, Sasaki H, Matsuda T, Mori E, Tsukada M, Fujii T
  • Organizer: The 4^<th> International Conference on Memory
  • Place of Presentation: Sydney, Australia
  • Year and Date: 20060716-21
• [Presentation] Reactivation of medial temporal lobe and occipital lobe during retrieval of color information : a PET study (2006)
  • Author(s): Ueno A, Abe N, Suzuki M, Mori E, Tashiro M, Itoh M, Fujii T
  • Organizer: 12th Annual meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Florence, Italy
  • Year and Date: 20060611-15
• [Presentation] Neural correlates of successful retrieval of 'person' as an information source of episodic memory : an event-related fMRI study (2006)
  • Author(s): Mugikura S, Abe N, Suzuki M, Ueno A, Higano S, Takahashi S, Fujii T
  • Organizer: 12th Annual meeting of the Organization for Human Brain Mapping
  • Place of Presentation: Florence, Italy
  • Year and Date: 20060611-15
• [Book] ヒトの海馬の機能イメ-ジング. 比較海馬学(渡辺茂, 岡市広成) (2008)
  • Author(s): 藤井俊勝, 鈴木麻希
  • Total Pages: 270-283
  • Publisher: ナカニシヤ出版
• [Book] The basal forebrain and episodic memory. In : Huston JP(ed) : Handbook of Behavioral Neuroscience Handbook of Episodic Memory, Dere E, Easton A, Nadel L, Huston JP(eds). Elsevier (2008)
  • Author(s): Fujii T
  • Total Pages: 343-362
  • Publisher: The Netherlands