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2008 Fiscal Year Final Research Report

Newly Developed Image Analysis Method of Tumor Blood Flow : Separate Quantitative Analysis of Intranodular Arterial and Portal Blood Flow and Its Application to Research on Hepatocarcinogenesis

Research Project

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Project/Area Number 18300176
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Medical systems
Research InstitutionKinki University

Principal Investigator

KUDO Masatoshi  Kinki University, 医学部, 教授 (10298953)

Co-Investigator(Kenkyū-buntansha) MURAKAMI Takamichi  近畿大学, 医学部, 教授 (20252653)
MUNAKATA Hiroshi  近畿大学, 医学部, 教授 (90111294)
Project Period (FY) 2006 – 2008
Keywords肝細胞癌 / 造影ハーモニック法 / Sonazoid / Pure arterial phase imaging / 結節内動脈血流 / 結節内門脈血流 / 早期肝癌 / 前癌病変
Research Abstract

今回われわれはraw data保存を利用して動脈血流と門脈血流を分離評価できる方法を開発した。新規超音波造影剤Sonazoidを用いることにより、そのraw data保存から検査後に腫瘍ならびに腫瘍の外側の動脈や門脈に関心領域(ROI)をおき、その立ち上がりから純粋に動脈のみで栄養される数秒間を装置内でコンピューター解析で同定し、その時間だけのMIP画像を加算してaccumulation画像を作成すると動脈が栄養しているか否かを判定し得ることを明らかにした。また、その後の門脈と動脈の両方が入るmixed phaseにおいては両者の交じり合ったこのphaseで血流が認められれば、それは門脈血流が存在する結節であることが評価できる。

  • Research Products

    (48 results)

All 2008 2007 Other

All Journal Article (46 results) (of which Peer Reviewed: 46 results) Presentation (2 results)

  • [Journal Article] Hepatocellular carcinooma 2009 and beyond : from the surveillance to molecular targeted therapy2008

    • Author(s)
      Kudo M
    • Journal Title

      Oncology 75

      Pages: S1-12

    • Peer Reviewed
  • [Journal Article] Epidemiology of hepatocellular carcinoma in Japan and Korea2008

    • Author(s)
      Kim SR, Kudo M, 他4名
    • Journal Title

      Oncology 75

      Pages: S13-16

    • Peer Reviewed
  • [Journal Article] Impact of Interferon therapy after curative treatment of hepatocellular carcinoma2008

    • Author(s)
      Kudo M
    • Journal Title

      Oncology 75

      Pages: S30-41

    • Peer Reviewed
  • [Journal Article] Sonazoid-enhanced ultrasonography for diagnosis of hepatic malignancies : comparison with contrast-enhanced CT2008

    • Author(s)
      Hatanaka K, Kudo M, 他2名
    • Journal Title

      Oncology 75

      Pages: S42-47

    • Peer Reviewed
  • [Journal Article] Imaging of hepatocellular carcinoma : qualitative and quantitative analysis of post-vascular phase contrast-enhanced US with Sonazoid ; comparison with superparamagnetic ironoxide magnetic resonance images2008

    • Author(s)
      Inoue T, Kudo M, 他10名
    • Journal Title

      Oncology 75

      Pages: S48-54

    • Peer Reviewed
  • [Journal Article] Intranodular blood supply correlates well with biological malignancy grade determined by tumor growth rate in pathologically proven hepatocellular carcinoma2008

    • Author(s)
      Kudo M, 他1名
    • Journal Title

      Oncology 75

      Pages: S48-54

    • Peer Reviewed
  • [Journal Article] Validation of a new prognostic staging system for heptaocellular carcinoma : a comparison of the biomarker combined Japan integrated staging(JIS) score, the conventional JIS score and the BALAD score2008

    • Author(s)
      Kitai S, Kudo M, 他8名
    • Journal Title

      Oncology 75

      Pages: S83-90

    • Peer Reviewed
  • [Journal Article] PIVKA-II is the best prognostic predictor in patients with hepatocellular carcinoma after radio frequency ablation therapy2008

    • Author(s)
      Takahashi S, KudoM, 他9名
    • Journal Title

      Oncology 75

      Pages: S91-98

    • Peer Reviewed
  • [Journal Article] Response evaluation of transcatheter arterial chemoembolizaion in hepatocellular carcinomas : the usefulness of Sonazoid-enhanced harmonic sonography2008

    • Author(s)
      Xia Y, Kudo M, 他13名
    • Journal Title

      Oncology 75

      Pages: S99-105

    • Peer Reviewed
  • [Journal Article] Combination therapy with S-1 and pegylated interferon alpha for advanced hepatocellular carcinoma2008

    • Author(s)
      Ueshima K, Kudo M, 他8名
    • Journal Title

      Oncology 75

      Pages: S106-113

    • Peer Reviewed
  • [Journal Article] Focal nodular hyperplasia-like lesion with venous washout in alcoholic liver cirrhosis2008

    • Author(s)
      Kim SR, KudoM, 他10名
    • Journal Title

      Internal Med 47

      Pages: 1899-1903

    • Peer Reviewed
  • [Journal Article] Multistep progression from a hypovascular nodule to a nodule-in-nodule type hepatocellular carcinoma in hepatitis C-related cirrhosis2008

    • Author(s)
      Madan K, Kudo M, 他1名
    • Journal Title

      Indian J Gastroenterol 27

      Pages: 176

    • Peer Reviewed
  • [Journal Article] Foreign body granuloma mimicking disseminated tumor reccurence after radiofrequency ablation for hepatocellular carcinoma2008

    • Author(s)
      Takahashi S, Kudo M, 他5名
    • Journal Title

      Liver Int 28

      Pages: 414-415

    • Peer Reviewed
  • [Journal Article] Surgical resection vs. percutaneous ablation for hepatocellular carcinoma : a preliminary report of the Japanese nationwide survey2008

    • Author(s)
      Hasegawa K, Kudo M, 他13名
    • Journal Title

      J Hepatol 49

      Pages: 589-594

    • Peer Reviewed
  • [Journal Article] Long-term follow-up of atypical progressive focal nodular hyperplasia increasing in size and number implicates its pathogenesis2008

    • Author(s)
      Kudo M, 他6名
    • Journal Title

      Am J Gastroenterol 103

      Pages: 2153-2155

    • Peer Reviewed
  • [Journal Article] Tumor markers after radio frequency ablation therapy for hepatocellular carcinoma2008

    • Author(s)
      Ogawa C, Kudo M, 他3名
    • Journal Title

      Hepato-Gastroenterol 55

      Pages: 1454-1457

    • Peer Reviewed
  • [Journal Article] Defect reperfusion imaing, a newly developed novel technology usine Sonazoid in the treatment of hepatocellular carcinoma2008

    • Author(s)
      Kudo M, 他2名
    • Journal Title

      J Med Ultrasound 16

      Pages: 169-175

    • Peer Reviewed
  • [Journal Article] Prognostic value of pretreatment levels of tumor markers for hepatocellular carcinoma on survival after curative treatment of patients with HCC2008

    • Author(s)
      Toyoda H, Kudo M, 他11名
    • Journal Title

      J Hepatol 49

      Pages: 223-232

    • Peer Reviewed
  • [Journal Article] Sonazoid-enhanced ultrasound in the diagnosis and treatment of hepatic tumors2008

    • Author(s)
      Kudo M, 他2名
    • Journal Title

      J Med Ultrasound 16

      Pages: 130-139

    • Peer Reviewed
  • [Journal Article] A new prognostic staging system for hepatocellular carcinoma : value of the biomarker combined Japan integrated staging score2008

    • Author(s)
      Kitai S, Kudo M, 他15名
    • Journal Title

      Intervirology 51

      Pages: S86-S94

    • Peer Reviewed
  • [Journal Article] Elevated serum ALT levels durinc pegylated interferon monotherapy may be caused by hepatic iron overload2008

    • Author(s)
      Nagashima M, Kudo M, 他5名
    • Journal Title

      Intervirology 51

      Pages: S76-S85

    • Peer Reviewed
  • [Journal Article] Usefulness of a new immunoradiometric assay of HCV core antigen to predict virological response during PEG-IFN/RBV combination therapy for chronic hepatitis with high viral load of serum HCV RNA genotye 1b2008

    • Author(s)
      Sasase N, Kudo M, 他10名
    • Journal Title

      Intervirology 51

      Pages: S70-S75

    • Peer Reviewed
  • [Journal Article] Differential diagnosis of hepatic tumors : value of contrast-enhanced harmonic sonography using the newly developed contrast agent, Sonazoid2008

    • Author(s)
      Hatanaka K, Kudo M, 他10名
    • Journal Title

      Intervirology 52

      Pages: S61-S69

    • Peer Reviewed
  • [Journal Article] Noninvasive evaluation of hepatic fibrosis using serum fibrotic markers, transient elastography (FibroScan), and real-time tissue2008

    • Author(s)
      Tatsumi C, Kudo M, 他10名
    • Journal Title

      Intervirology 51

      Pages: S27-S33

    • Peer Reviewed
  • [Journal Article] Diagnostic accuracy of imaging for liver cirrhosis compared to histologically proven liver cirrhosis2008

    • Author(s)
      Kudo M, 他13名
    • Journal Title

      Intervirology 51

      Pages: S17-S26

    • Peer Reviewed
  • [Journal Article] Radiofrequency ablation of hepatocellular carcinoma : value of virtual CT sonography with magnetic navigation2008

    • Author(s)
      Minami Y, Kudo M, 他6名
    • Journal Title

      AJR Am J Roentgenol 190

      Pages: W335-341

    • Peer Reviewed
  • [Journal Article] Lone-term outcome of percutaneous ethanol injection therapy for minimum-sized hepatocellular carcinoma2008

    • Author(s)
      Taniguchi M, Kudo M, 他9名
    • Journal Title

      World J Gastroenterol 14

      Pages: 1997-2002

    • Peer Reviewed
  • [Journal Article] Comparison of three current staging systems for hepatocellular carcinoma : Japan integrated staging score, new Barcelona clinic liver cancer staging classification, and Tokyo score2008

    • Author(s)
      Chung H, Kudo M, 他8名
    • Journal Title

      J Gastroenterol Hepatol 23

      Pages: 445-452

    • Peer Reviewed
  • [Journal Article] Molecular mechanisms of portal vein tolerance2008

    • Author(s)
      Watanabe T, Kudo M, 他2名
    • Journal Title

      Hepatol Res 38

      Pages: 441-449

    • Peer Reviewed
  • [Journal Article] Comparison of the outcomes between an anatomical subsegmentectomy and a non-anatomical minor hepatectomy for single hepatocellular carcinomas based on a Japanese nationwide survey2008

    • Author(s)
      Eguchi S, Kudo M, 他12名
    • Journal Title

      Surgery 143

      Pages: 469-475

    • Peer Reviewed
  • [Journal Article] Preliminary study of contrast-enhanced harmonic endosonography with second-generation contrast agents2008

    • Author(s)
      Kitano M, Kudo M, 他8名
    • Journal Title

      J Med Ultrasonics 35

      Pages: 11-18

    • Peer Reviewed
  • [Journal Article] Mixed intenstinal- and diffuse-type histology is a risk factor for lymph node metastasis of submucosal invasive gastric cancer2008

    • Author(s)
      Tsuji N, Kudo M, 他2名
    • Journal Title

      Digest Endosc 20

      Pages: 17-21

    • Peer Reviewed
  • [Journal Article] Treatment of large and/or multiple hepatic malignancies : open surgical approaches of radio frequency ablation2007

    • Author(s)
      Minami Y, Kudo M, 他8名
    • Journal Title

      Hepato-Gastroenterol 54

      Pages: 2358-2360

    • Peer Reviewed
  • [Journal Article] Combination therapy with PEG-IFN-alpha and 5-FU inhibits HepG2 tumor cell growth in nude mice by apoptosis of p532007

    • Author(s)
      Hagiwara S, Kudo M, Munakata H, 他6名
    • Journal Title

      Brit J Cancer 97

      Pages: 1532-1537

    • Peer Reviewed
  • [Journal Article] Case of rapidly progressed sarcomatoid hepatocellular carcinoma in young female without risk factor2007

    • Author(s)
      InoueT, KudoM, 他4名
    • Journal Title

      Liver Int 27

      Pages: 1428-1430

    • Peer Reviewed
  • [Journal Article] Long-term interferon maintenance therapy improves survival in patients with HCV-related hepatocellular carcinoma after curative radiofrequency ablation : a matched case-control study2007

    • Author(s)
      Kudo M, 他10名
    • Journal Title

      Oncology 72

      Pages: S132-S138

    • Peer Reviewed
  • [Journal Article] Percutaneous radiofrequency ablation of sonographically unidentifiable liver tumors : Feasibility and usefulness of a novel guiding technique with an integrated system of computed tomography and sonographic images2007

    • Author(s)
      Minami Y, Kudo M, 他10名
    • Journal Title

      Oncology 72

      Pages: S111-S116

    • Peer Reviewed
  • [Journal Article] Initial treatment response is essential to improve survival in patients with heptocellular carcinoma who underwent curative radiofrequency ablation therapy2007

    • Author(s)
      Takahashi S, Kudo M, 他9名
    • Journal Title

      Oncology 72

      Pages: S98-S103

    • Peer Reviewed
  • [Journal Article] What is the best time to evaluate treatment response after radio frequency ablation of hepatocellular carcinoma using contrast-enhanced sonography?2007

    • Author(s)
      Zhou P, Kudo M, 他5名
    • Journal Title

      Oncology 72

      Pages: S92-S97

    • Peer Reviewed
  • [Journal Article] Severe complications of radiofrequency ablation therapy for hepatocellular carcinoma : an analysis of 3,891 ablations in 2,614 patients2007

    • Author(s)
      Kasugai H, Kudo M, 他3名
    • Journal Title

      Oncology 72

      Pages: S72-S75

    • Peer Reviewed
  • [Journal Article] Multicentric occurrence of HCC detected 3-4 yerars after AFP-L3 positivity

    • Author(s)
      Kim SR, Kudo.M, 他12名
    • Journal Title

      Internal Med 2009 (in press)

    • Peer Reviewed
  • [Journal Article] Value of liver parenchymal phase imaging of contrast-enhanced ultrasonography to diagnose the premalignant/borderline lesions and overt HCC.

    • Author(s)
      Inoue T, Kudo M, 他5名
    • Journal Title

      AJR Am J Roentgenol 2009 (in press)

    • Peer Reviewed
  • [Journal Article] Multistep human hepatocarcinogenesis : correlation of imageing with pathology

    • Author(s)
      Kudo M
    • Journal Title

      J Gastroenterol 2009 (in press)

    • Peer Reviewed
  • [Journal Article] International consensus on the pathologic diagnosis of early hepatocellular carcinoma : A report of the international consensus group for hepatocellular neoplasia

    • Author(s)
      Wanless I, Kudo M, 他24名
    • Journal Title

      Hepatology 2009 (in press)

    • Peer Reviewed
  • [Journal Article] Two cases of non-alcoholic steato-hepatitis developing from simple fatty liver

    • Author(s)
      Kim SR, Kudo M, 他10名
    • Journal Title

      J Hepatol 2009 (in press)

    • Peer Reviewed
  • [Journal Article] Pegylated interferon plus ribavirin combination therapy for chronic hepatitis C with high viral load of serum HCV RNA, genotype 1b, discontinued on attaining sustained virological response in week 16 after onset of acute pancreatitis

    • Author(s)
      Kim SR, Kudo M, 他2名
    • Journal Title

      J Gastroint Liver Dis 2009 (in press)

    • Peer Reviewed
  • [Presentation] Treatment of single HCC in 2-5cm : Debate on gray zone. Non-surgical treatment : Eastern experience2008

    • Author(s)
      Kudo M
    • Organizer
      6thInternational Meeting Hepatoce llular Carcinoma : Eastern and Western Experiences Current Issues of Hepatocellular Carcinoma
    • Place of Presentation
      Korea
    • Year and Date
      2008-12-12
  • [Presentation] 進行肝細胞に対するS-1,ペグインターフェロン併用療法2008

    • Author(s)
      上嶋一臣
    • Organizer
      第49回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Year and Date
      2008-05-09

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Published: 2010-06-10   Modified: 2016-04-21  

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