2009 Fiscal Year Final Research Report
The Clarification of the expression mechanism of functional molecules on human lymphatic endothelium in oral cavity
| Project/Area Number |
18390483
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Hokkaido University |
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Principal Investigator |
YOSHIDA Shigemitsu Hokkaido University, 名誉教授 (80174928)
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| Co-Investigator(Kenkyū-buntansha) |
ISHISAKI Akira 岩手医科大学, 歯学部, 教授 (20356439)
DOMON Takanori 北海道大学, 大学院・歯学研究科, 教授 (50217618)
ASHIKAGA Yuichi 北海道大学, 大学院・歯学研究科, 助教 (70372258)
INOUE Kiichiro 北海道大学, 大学院・歯学研究科, 助教 (30168439)
KUROSHIMA Shinichiro 北海道大学, 大学院・歯学研究科, 助教 (40443915)
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| Co-Investigator(Renkei-kenkyūsha) |
SAWA Yoshihiko 福岡歯科大学, 歯学部, 教授 (70271666)
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| Project Period (FY) |
2006 – 2009
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| Keywords | リンパ管内皮細胞 / 白血球接着因子 / ケモカイン / 口腔組織 |
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| Research Abstract |
We investigated some proteins which play an important role in the immune system to clarify immune mechanisms via intraoral and extraoral lymphatic vessels. We showed that intraoral lymphatic vessels may differently play site-specific roles in immune systems, and extraoral lymphatic vessels have intracellular networks through these proteins. We discovered that systemic lymphatic vessels contribute to not only substance transport, but also immune mechanisms.
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[Journal Article] LPS-induced IL-6, IL-8, VCAM-1, and ICAM-1 expression in human lymphatic endothelium2008
Author(s)
Sawa Y, Ueki T, Hata M, Iwasawa K, Tsuruga E, Kojima H, Ishikawa H, Yoshida S.
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Journal Title
J Histochem Cytochem 56(2)
Pages: 97-109
Peer Reviewed
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