2007 Fiscal Year Final Research Report Summary
Stabilization of "Asymmetric Oxygen" derived from Metal-Coordinated Oxygen Atom
| Project/Area Number |
18550059
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Inorganic chemistry
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| Research Institution | Nara Women's University |
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Principal Investigator |
MIKATA Yuji Nara Women's University, KYOUSEI Science Center for Life and Nature, Associate Professor (10252826)
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| Project Period (FY) |
2006 – 2007
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| Keywords | Asymmetric Oxygen Atom / Metal Coordination / Metal Complex / Ether Oxygen / Chirality / Asymmetric Coordination / O-Glycoside / S-Glycoside |
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| Research Abstract |
It is well known that a nitrogen lone pair inverts via pyramidal inversion, causing expeditious loss of chirality at a stereogenic nitrogen center. But metal-coordinated nitrogen atoms have been demonstrated as an asymmetric nitrogen. Similarly, it is possible that the oxygen atom of a unsymmetrical ether can become a chiral center when coordinated to a metal ion. In this case also, the chirality is extremely unstable due to the rapid inversion of the remaining oxygen lone pair. Preventing lone pair inversion by metal ion coordination is a potential route to compounds exhibiting a chiral oxygen atom. Strong coordination of the metal ion to the ether oxygen atom may lead to the necessary differentiation of the two oxygen lone pairs. Careful ligand design is needed in any effort to isolate a compound with a metal-bound asymmetric oxygen atom. In this project, controlling factors for the assembly of asymmetric oxygen atoms are discussed, including the effect of ligand structure, counterion, and solvent in a series of dipicolylamine-copper (II) complexes
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Research Products
(41 results)
