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2007 Fiscal Year Final Research Report Summary

Morphofimctional analysis ofGalanin-lice Peptide on regulation offeeding and enegy metabolism

Research Project

Project/Area Number 18590176
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field General anatomy (including Histology/Embryology)
Research InstitutionShowa University

Principal Investigator

GUAN Jian-Lian  Showa University, Dept. of Anatomy, Sch. of Med., Assistant Professor (20276538)

Co-Investigator(Kenkyū-buntansha) SHIODA Seiji  Showa University, Department of Analomy School of Medicine, Professor (80102375)
ARATA Satoru  Showa Univ., Center for Biotechnology, Associate Professor (20159502)
OSAKA Toshimasa  National Institute of Health and Nutrition, 栄養所要量研究部, Senior Researcher (30152101)
Project Period (FY) 2006 – 2007
KeywordsGalanin-like peptide / afferent neuron / energy metabolism / Transgenic mice / neuron network
Research Abstract

The hypothalamus plays a critical role in regulation of feeding behavior, energy metabolism and reproduction. A novel peptide discovered in porcine hypothalamus has 60 amino acid peptide and a non-amidated C-terminus. Since a portion of this peptide is homology with galanin, it is named galanin-like peptide (GALP). GALP is mainly produced in the hypothalamic arcuate nucleus. GALP acts in the central nervous system, where it is involved in the regulation of feeding behavior. GALP-producing neurons were shown to make neuron networks with several feeding related peptide-producing neurons in the hypothalamus. Since GALP controls food intake and energy balance, it is possible that GALP is an important factor in development of obesity. Furthermore, we have succeeded to make transgenic (Tg) mice that express enhanced green fluorescence (EGFP) in GALP-containing neurons and also to make Tg mice that express EGFP in afferent GALP neurons in brain. As a result, we have first shown that GALP-containing neurons make synaptic input from the pyriform cortex and amygdala. Therefore, GALP may involve in feeding behavior, energy metabolism and reproduction, further studies on the morphology and function of GALP should continue to demonstrate further the understanding in brain function.

  • Research Products

    (13 results)

All 2008 Other

All Journal Article (12 results) (of which Peer Reviewed: 3 results) Presentation (1 results)

  • [Journal Article] Visualization of ghrelin-producing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice2008

    • Author(s)
      Kageyama H.
    • Journal Title

      Regul Pept. 145

      Pages: 116-121

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Synaptic relationships between proopiomelanocortin-and ghrelin-containing neurons in the rat arcuate nucleus2008

    • Author(s)
      Guan JL.
    • Journal Title

      Regul Pept. 145

      Pages: 128-132

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Synaptic interaction between ghrelin-and ghrelin-containing neurons in the rat hypothalamus2008

    • Author(s)
      Hori Y.
    • Journal Title

      Regul Pept. 145

      Pages: 122-127

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] 2006 Galanin-like peptide promotes feeding behaviour via activation of orexinergic neurones in the rat lateral hypothalamus

    • Author(s)
      Kageyama, H, Kita, T, Toshinai, K, Guan, JL, Date, Y, Takenoya, F, Kato, S, Matsumoto, H, Ohtaki, T, Nakazato M, Shioda, S
    • Journal Title

      J Neuroendocrinol 18

      Pages: 33-41

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 2006 Central administration of melanin-concentrating hormone(MCH) suppresses food intake, but not locomotor activity, in the goldfish, Carassius auratus

    • Author(s)
      Matsuda, K, Shimakura, S, Maruyama, K, Miura, T, Uchiyama, M, Kawauchi, H, Shioda, S, Takahashi, A
    • Journal Title

      Neurosci Lett 399

      Pages: 259-63

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 2006 Neural interaction between galanin-like peptide(GALP)- and luteinizing hormone-releasing hormone(LHRH)-containing neurons

    • Author(s)
      Takenoya, F, Guan, JL, Kato, M, Sakuma, Y, Kintaka, Y, Kitamura, Y, Kitamura, S, Okuda, H, Takeuchi, M, Kageyama, H, Shioda, S
    • Journal Title

      Peptides 27

      Pages: 2885-93

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 2006 Peripheral ghrelin transmits orexigenic signals through the noradrenergic pathway from the hindbrain to the hypothalamus

    • Author(s)
      Date, Y, Shimbara, T, Koda, S, Toshinai, K, Ida, T, Murakami, N, Miyazato, M, Kokame, K, Ishizuka, Y, Ishida, Y, Kageyama, H, Shioda, S, Kangawa, K, Nakazato, M
    • Journal Title

      Cell Metab 4

      Pages: 323-31

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 2008 Visualization of ghrelin-producing neurons in the hypothalamic arcuate nucleus using ghrelin-EGFP transgenic mice

    • Author(s)
      Kageyama, H, Kitamura, Y, Hosono, T, Kintaka, Y, Seki, M, Takenoya, F, Hori, Y, Nonaka, N, Arata, S, Shioda, S
    • Journal Title

      Regul Pept 145

      Pages: 116-21

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 2008 Synaptic interaction between ghrelin- and ghrelin-containing neurons in the rat hypothalamus

    • Author(s)
      Hori, Y, Kageyama, H, Guan, JL, Kohno, D, Yada, T, Takenoya, F, Nonaka, N, Kangawa, K, Shioda, S, Yoshida, T
    • Journal Title

      Regul Pept 145

      Pages: 122-7

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 2008 Synaptic relationships between proopiomelanocortin- and ghrelin-containing neurons in the rat arcuate nucleus

    • Author(s)
      Guan, JL, Okuda, H, Takenoya, F, Kintaka, Y, Yagi, M, Wang, L, Seki, M, Hori, Y, Kageyama, H, Shioda, S
    • Journal Title

      Regul Pept 145

      Pages: 128-32

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 2008 Neuronal interactions between neuropeptide W- and orexin- or melanin-concentrating hormone-containing neurons in the rat hypothalamus

    • Author(s)
      Takenoya, F, Kitamura, S, Kageyama, H, Nonaka, N, Seki, M, Itabashi, K, Date, Y, Nakazato, M, Shioda, S
    • Journal Title

      Regul Pept 145

      Pages: 159-64

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] 2008 Morphological interaction between galanin-like peptide- and dopamine-containing neurons in the rat arcuate nucleus

    • Author(s)
      Kageyama, H, Takenoya, F, Hori, Y, Yoshida, T, Shioda, S
    • Journal Title

      Regul Pept 145

      Pages: 165-8

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 摂食調節ニューロンの求心性神経回路網の形態機能解析2008

    • Author(s)
      影山 晴秋
    • Organizer
      第113回日本解剖学会総会、全国学術集会
    • Place of Presentation
      大分大学医学部
    • Year and Date
      20080327-29
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-02-04  

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