Neuroendocrine mechanism for determination of sexual orientation in the rat

2009 Fiscal Year Final Research Report

• Project/Area Number: 18590225
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: Nippon Medical School
• Principal Investigator: KONDO Yasuhiko Nippon Medical School, 医学部, 講師 (00192584)
• Project Period (FY): 2006 – 2009
• Keywords: 性行動 / 性分化 / 生殖 / 性指向性 / 哺乳類

Research Abstract

When being given a pair of odors of sexually active males and estrous females, sexually mature male rats show vigorous exploration toward the estrous odors while receptive female rats palpably prefer for sexual male odors to estrous odors. This sex difference in olfactory preference may reflect their sexual orientation. Our earlier studies of this project showed that those sexual dimorphic olfactory preferences are based on sensory signals received by the olfactory epithelium (OE) but not by the vomeronasal organ (VNO) which is believed to be involved in pheromonal perception. In the brain, we elucidated that olfactory preference of male rats is critically regulated in the medial preoptic area that receives olfactory signals through multiple pathways, including the amygdala nuclei.

Research Products

• [Journal Article] Similar numbers of neurons are generated in the male and female rat preoptic area in utero. (2010)
  • Author(s): Orikasa, C., Kondo, Y., Usui, S., Sakuma, Y
  • Journal Title: Neuroscience Research (in press)
• [Journal Article] Maternal isobutyl-paraben exposure alters anxiety and passive avoidance test performance in adult male rats. (2009)
  • Author(s): Kawaguchi, M., Irie, K., Morohoshi K., Watanabe, G., Taya, K., Morita, M., Kondo, Y., Imai, H., Himi, T
  • Journal Title: Neuroscience Research 65 Pages: 136-140
• [Journal Article] 性指向性の決定機構 (2009)
  • Author(s): 近藤保彦・佐久間康夫
  • Journal Title: Clinical Neuroscience 27 Pages: 1126-1127
• [Journal Article] オキシトシン. 実地医家のためのKey Word解説 (2009)
  • Author(s): 近藤保彦・佐久間康夫
  • Journal Title: Medical Forum CHUGAI 13 Pages: 45
• [Journal Article] 性的動機づけ(性欲)評価のための動物実験 (2008)
  • Author(s): 近藤保彦
  • Journal Title: アニテックス 20 Pages: 18-22
• [Journal Article] 幼若期の生育環境と性衝動-動物モデルからの検討 (2008)
  • Author(s): 近藤保彦
  • Journal Title: 現代性教育研究月報 26 Pages: 8-9
• [Journal Article] Transient transcription of the somatostatin gene at the time of estrogen-dependent organization of the sexually dimorphic nucleus of the rat preoptic area. (2007)
  • Author(s): Orikasa, C., Kondo, Y., Sakuma, Y
  • Journal Title: Endocrinology 148 Pages: 1144-1149
• [Journal Article] Dehydroepiandrosterone alleviates copulatory disorder induced by social stress in male rats. (2006)
  • Author(s): Mizuno, T., Yotsuyanagi, S., Kondo, Y., Komatsu, K., Ishiura, Y., Nakamura, Y., Nagasaka, Y., Yokoyama, O., Namiki, M
  • Journal Title: Journal of Sexual Medicine, Erratum: Journal of Sexual Medicine 3 Pages: 612-618, 1090
• [Presentation] Gonadal steroid action on sexual preference in adult rat brain. (2010)
  • Author(s): Kondo, Y
  • Organizer: 14th International Congress of Endo- crinology (ICE2010) JES-Sponsored Symposium "Brain Sex Differentiation and It's Plasticity"
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20100000
• [Presentation] Ontogeny of somatostatin neurons in the sexually dimorphic nucleus of the rat preoptic area. (2009)
  • Author(s): Orikasa, C., Kondo, Y., Usui, S., Sakuma, Y
  • Organizer: The 36th International Congress of Physio- logical Science
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090000
• [Presentation] Olfactory preference of male rats after destruction of the medial amygdala or the medial pre- optic area. (2009)
  • Author(s): Dhungel S., Urakawa, S., Kondo, Y., Sakuma, Y
  • Organizer: The 36th International Congress of Physiological Science
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090000
• [Presentation] The necessity of oxytocin in devel- opment of male mouse ultrasonic vocal- ization in response to female odor. (2009)
  • Author(s): Kondo, Y., Kromkhum, P., Tanaka, M., Nishimori, K., Saito, T.R., Sakuma, Y
  • Organizer: The 36th International Congress of Physiol- ogical Science
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 20090000
• [Presentation] Dual pathways of ol- factory input to the preoptic area regulating conspecific odor preference of male rats. (2009)
  • Author(s): Dhungel S., Kondo, Y., Masaoka, M., Sakuma, Y
  • Organizer: Society for Neuroscience, the 40th Meeting
  • Place of Presentation: Chicago, IL
  • Year and Date: 20090000
• [Presentation] Sex steroids and the establishment of the sexually dimor- phic nucleus of the rat preoptic area. (2009)
  • Author(s): Orikasa, C., Kondo, Y., Usui, S., Sakuma, Y
  • Organizer: Society for Neuroscience, the 40th Meeting
  • Place of Presentation: Chicago, IL
  • Year and Date: 20090000
• [Presentation] Maternal ibobutyl-paraben exposure alters anxiety, learning performance, and social recognition in adult rats. (2009)
  • Author(s): 川口真以子・諸星佳織・渡辺元・田谷一善・森田昌敏・近藤保彦・今井秀樹・氷見敏行
  • Organizer: 第36回日本神経内分泌学会
  • Place of Presentation: 小倉
  • Year and Date: 20090000
• [Presentation] Sex differ- ence in hormonal and neural regula- tion of olfactory preference for conspe- cifics in the rat. (2008)
  • Author(s): Kondo, Y., Sakuma, Y
  • Organizer: The physiological society of Japan Symposium for "New perspectives on hormonal bases of reproductive behavior. "
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20080000
• [Presentation] 他個体の社会信号受容に影響する心理学的因子 (2008)
  • Author(s): 近藤保彦
  • Organizer: 日本心理学会第72回大会シンポジウム「こころに作用するホルモン」
  • Place of Presentation: 札幌
  • Year and Date: 20080000
• [Presentation] Male rat sexual preference can be revered by estrogen action in adults. (2008)
  • Author(s): Kondo, Y., Sakuma, Y
  • Organizer: Session 7: Steroid Hormones and Sex Differences in Brain and Behavior. US/JAPAN Neurosteroid Symposium 2008
  • Place of Presentation: Gifu, Japan
  • Year and Date: 20080000
• [Presentation] Factors in recipient for chemosensory communication of rodent. (2008)
  • Author(s): Kondo, Y
  • Organizer: JAPAN/CHINA Joint Symposium for "Strategies to Reduce Risks on the Brain Development Contingent to Urbanization"
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 20080000
• [Presentation] セロトニン神経と雄性行動 (2008)
  • Author(s): 近藤保彦
  • Organizer: 第2回日本医科大学・早稲田大学共催シンポジウム「セロトニンと人間」
  • Year and Date: 20080000
• [Presentation] Oxytocin is required for developing ultrasonic vocalization in mouse mating. (2008)
  • Author(s): Kondo, Y., Saeki, T., Takahashi, Y., Tanaka, M., Nishimori, K., Saito, T.R., Sakuma, Y
  • Organizer: Society for Behav- ioral Neuroendocrinology
  • Place of Presentation: Groningen, Netherland
  • Year and Date: 20080000
• [Presentation] Generation of the somatostatin neurons in the sex- ually dimorphic nucleus of the rat pre optic area. (2008)
  • Author(s): Orikasa, C., Kondo, Y., Urakawa, S., Usui, S., Sakuma, Y
  • Organizer: Society for Behavioral Neuroendocrinology
  • Place of Presentation: Groningen, Neth- erland
  • Year and Date: 20080000
• [Presentation] Conspecific olfactory preferences of male rats carrying lesions of the medial amygdala or the preoptic area. (2008)
  • Author(s): Dhungel, S., Kondo, Y., Sakuma, Y
  • Organizer: Poster Session in US/JAPAN Neurosteroid Symposium 2008
  • Place of Presentation: Gifu, Japan
  • Year and Date: 20080000
• [Presentation] Functional differences of the medial amygdala and medial preoptic area in regulation of con- specific odor preferences. (2008)
  • Author(s): Dhungel, S., Urakawa, S., Kondo, Y., Sakuma, Y
  • Organizer: JAPAN/ CHINA Joint Symposium for "Strat- egies to Reduce Risks on the Brain Development Contingent to Urbani- zation"
  • Place of Presentation: Tsukuba, Japan
  • Year and Date: 20080000
• [Presentation] 雄マウスの交尾時超音波発声の発達におけるオキシトシンの役割 (2008)
  • Author(s): 近藤保彦・佐伯知香・高橋弥生・田中実・西森克彦・齊藤徹・佐久間康夫
  • Organizer: 日本動物心理学会第68回大会
  • Place of Presentation: 水戸
  • Year and Date: 20080000
• [Presentation] 生育環境とストレス反応性・性行動.シンポジウム「ストレスと性機能障害」 (2007)
  • Author(s): 近藤保彦・浦川将・佐久間康夫
  • Organizer: 第17回日本性機能学会中部総会
  • Place of Presentation: 福井
  • Year and Date: 20070000
• [Presentation] 幼若期の生育環境と性衝動-動物モデルからの検討 (2007)
  • Author(s): 近藤保彦
  • Organizer: 第52回日本=性研究会議
  • Place of Presentation: 東京
  • Year and Date: 20070000
• [Presentation] Sexual behavior in male rats reared in conventional and enriched environment. (2007)
  • Author(s): Urakawa, S., Kondo, Y., Mitsushima, D., Sakuma, Y
  • Organizer: Society for Be- havioral Neuroendocrinology
  • Place of Presentation: Pacific Grove, CA
  • Year and Date: 20070000
• [Presentation] Medial amygdala and preoptic area regulate conspecific odor preference in male rat. (2007)
  • Author(s): Dhungel, S., Urakawa, S., Kondo, Y., Sakuma, Y
  • Organizer: Society for Be- havioral Neuroendocrinology
  • Place of Presentation: Pacific Grove, CA
  • Year and Date: 20070000
• [Presentation] 雄ラットの性指向性調節における扁桃体内側核および内側視索前野の役割 (2007)
  • Author(s): ドゥンゲルスニル・浦川将・近藤保彦・佐久間康夫
  • Organizer: 第84回日本生理学会大会発表
  • Place of Presentation: 大阪
  • Year and Date: 20070000
• [Presentation] 豊かな環境は雄ラット性行動時の社会的接触を減少させる (2007)
  • Author(s): 浦川将・近藤保彦・西野仁雄・佐久間康夫
  • Organizer: 第84回日本生理学会大会発表
  • Place of Presentation: 大阪
  • Year and Date: 20070000
• [Presentation] 幼少期における豊かな環境飼育はオープンフィールドでの雄ラット性行動を減弱する (2007)
  • Author(s): 浦川将・近藤保彦・美津島大・西野仁雄・佐久間康夫
  • Organizer: 日本神経科学学会第30回大会
  • Place of Presentation: 横浜
  • Year and Date: 20070000
• [Presentation] Functional diversity of the medial amygdala and the preoptic area in controlling sexual preference of male rats. (2007)
  • Author(s): ドゥンゲルスニル・浦川将・近藤保彦・佐久間康夫
  • Organizer: 日本動物心理学会第67回大会
  • Place of Presentation: 東京
  • Year and Date: 20070000
• [Presentation] 豊かな環境飼育は新奇環境下での雄ラット性行動亢進を減弱する (2007)
  • Author(s): 浦川将・近藤保彦・美津島大・下鶴倫人・佐久間康夫
  • Organizer: 日本動物心理学会第67回大会
  • Place of Presentation: 東京
  • Year and Date: 20070000
• [Presentation] 成熟後も維持される雄ラット性指向性の性ホルモン依存性 (2006)
  • Author(s): 近藤保彦・肖凱・佐久間康夫
  • Organizer: 学術フロンティア「脳機能の性差形成機構」公開シンポジウム
  • Place of Presentation: 早稲田
  • Year and Date: 20060000
• [Presentation] 雄マウスにおける射精後性行動抑制メカニズム (2006)
  • Author(s): 近藤保彦
  • Organizer: 第15回神経行動薬理若手研究者の集い, ミニシンポジウム「性を主題とした神経・行動・薬理研究」
  • Place of Presentation: 千葉
  • Year and Date: 20060000
• [Presentation] 性成熟後に見られる雄セット性指向性の柔軟性.ワークショップ「日本における行動神経内分泌学研究の動向」 (2006)
  • Author(s): 近藤保彦
  • Organizer: 日本動物心理学会第66回大会
  • Place of Presentation: 京都
  • Year and Date: 20060000
• [Presentation] Olfactory conditioning of copulatory behavior in male mice. (2006)
  • Author(s): Kondo, Y., Sobukawa, A., Katou, M., Sakuma, Y., Saito, T. R
  • Organizer: Society for Behavioral Neuroendocrinology
  • Place of Presentation: Pittsburgh, PA
  • Year and Date: 20060000
• [Presentation] Sexually dimorphic exression of somat- ostatin gene in the developing rat preoptic area. (2006)
  • Author(s): Orikasa, C., Kondo, Y., Sakuma, Y
  • Organizer: Society for Behavioral Neuroendocrinology
  • Place of Presentation: Pittsburgh, PA
  • Year and Date: 20060000
• [Presentation] Effects of opiate antagonist on mating- induced conditioned place preference in female rats. (2006)
  • Author(s): Yamada, K., Horibe, S., Kondo, Y
  • Organizer: Society for Behavioral Neuroendocrinology
  • Place of Presentation: Pittsburgh, PA
  • Year and Date: 20060000
• [Presentation] ラット視索前野性的二型核に発現するソマトスタチンの性差 (2006)
  • Author(s): 折笠千登世・近藤保彦・佐久間康夫
  • Organizer: 日本神経科学学会第29回大会発表
  • Place of Presentation: 京都
  • Year and Date: 20060000
• [Presentation] 雌ラットの性行動による条件性場所選好に及ぼすナロキソン投与の効果 (2006)
  • Author(s): 堀部晨, 近藤保彦, 岩崎庸男, 山田一夫
  • Organizer: 日本動物心理学会第66回大会
  • Place of Presentation: 京都
  • Year and Date: 20060000
• [Presentation] 雌マウス性行動における嗅覚条件付け (2006)
  • Author(s): 近藤保彦・曽布川亜弓・加藤雅裕・佐久間康夫・斎藤徹
  • Organizer: 日本動物心理学会第66回大会
  • Place of Presentation: 京都
  • Year and Date: 20060000
• [Presentation] 豊かな飼育環境によってもたらされる雄ラット社会行動の変化 (2006)
  • Author(s): 浦川将・近藤保彦・佐久間康夫
  • Organizer: 日本動物心理学会第66回大会
  • Place of Presentation: 京都
  • Year and Date: 20060000
• [Book] 脳とホルモンの行動学-行動神経内分泌学への招待 (2010)
  • Author(s): 近藤保彦・小川園子・菊水健史・山田一夫・富原一哉編
  • Publisher: 西村書店
• [Book] 心理学検定模擬問題集「神経・生理領域」(日本心理学諸学会連合心理学検定局編) (2009)
  • Author(s): 近藤保彦(領域別執筆責任者)
  • Publisher: 実務教育出版
• [Book] 心理学検定重要キーワード集「神経・生理領域」(日本心理学諸学会連合心理学検定局編) (2009)
  • Author(s): 近藤保彦(領域別執筆責任者)
  • Publisher: 実務教育出版
• [Remarks] 小川園子・近藤保彦・山田一夫・菊水健史.日本における行動神経内分泌学研究の動向.日本動物心理学会第66回大会ワークショップ企画,Oct 13, 2006
• [Remarks] 近藤保彦・小川園子・菊水健史・山田一夫.社会行動を制御するホルモンダイナミズム.行動神経内分泌研究会キックオフシンポジウム・第33回日本神経内分泌学会サテライトシンポジウム企画,Oct 28, 2006
• [Remarks] 近藤保彦・富原一哉.心理学における神経内分泌学.日本心理学会第70回大会ワークショップ企画, Nov 3, 2006
• [Remarks] 近藤保彦・富原一哉.初期経験がつくる「こころ」と「脳」の発達.日本心理学会第71回大会ワークショップ企画, Sep 19, 2007
• [Remarks] 近藤保彦・和田博美.こころに作用するホルモン.日本心理学会第72回大会シンポジウム企画(札幌),Sep 19, 2008
• [Remarks] 近藤保彦.人と人とをつなぐホルモン.神奈川健生クラブ10周年記念の集い「招待講演」, 2008
• [Remarks] 高瀬堅吉・近藤保彦・富原一哉.男のこころ、女のこころ-その生物学的基盤を探る.日本心理学会第73回大会ワークショップ企画, Aug 26, 2009
• [Remarks] 近藤保彦.ホルモンと匂いが織りなす人間模様- 社会行動の生物学的基礎.第24回北海道大学心理学コロキウム・日本認定心理士会北海道・東北支部第21回研修会, Sept 17, 2009
• [Remarks] 小川園子・近藤保彦・和田博美・富原一哉・山田一夫・菊水健史.周生期・周産期の内分泌かく乱は心と行動に何をもたらすのか?日本動物心理学会第69回大会ワークショップ企画,Sept 25, 2009