Personalized prevention using the information of longevity-associated mitochondrial DNA polymorphism

2008 Fiscal Year Final Research Report

• Project/Area Number: 18590572
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hygiene
• Research Institution: Showa University (2007-2008); Kyorin University (2006)
• Principal Investigator: KOKAZE Akatsuki Showa University, 医学部, 教授 (70271583)
• Project Period (FY): 2006 – 2008
• Keywords: 遺伝子多型 / ミトコンドリア / 長寿 / 生活習慣 / 予防医学

Research Abstract

長寿関連ミトコンドリア遺伝子多型(Mt5178C/A多型)と飲酒習慣との高血圧症リスクおよび高尿酸血症リスクへの交互作用、Mt5178C/A多型と喫煙習慣との呼吸機能への交互作用、Mt5178C/A多型とコーヒー飲用との高血圧症リスクおよび耐糖能異常リスクへの交互作用を論文発表した. また、Mt5178C/A多型と心血管疾患の危険因子の重積との関連について検討し、Mt5178C型の男性においては毎日の飲酒が心血管疾患危険因子の重積と関連することを学会報告した.

Research Products

• [Journal Article] Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men (2007)
  • Author(s): Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Masao Yoshida, Masao Satoh, Koji Teruya, Rie Honmyo, Takako Shirasawa, Hiromi Hoshino, Yutaka Takashima
  • Journal Title: J. Hum. Genet 52 Pages: 680-685
  • Peer Reviewed
• [Journal Article] NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Japanese men (2007)
  • Author(s): Akatsuki Kokaze, Mamoru Ishikawa, Naomi atsunaga, Masao Yoshida, Masao Satoh, Koji Teruya, Yumi Matsuda, Rie Honmyo, Yoshiko Uchida, Yutaka Takashima
  • Journal Title: Hypertens. Res 30 Pages: 213-218
  • Peer Reviewed
• [Journal Article] Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men (2006)
  • Author(s): Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Masao Yoshida, Masao Satoh, Koji Teruya, Rie Honmyo, Misako Yorimitsu, Yumi Masuda, Yoshiko Uchida, Yutaka Takashima
  • Journal Title: J. Hum. Genet 51 Pages: 765-771
• [Journal Article] Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on reduced risk of hypertension in middle-aged Japanese men
  • Author(s): Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Masao Yoshida, Tadahiro Ohtsu, Takako Shirasawa, Hideaki Sekii, Taku Ito, Teruyoshi Kawamoto, Yutaka Takashima
  • Journal Title: J. Epidemiol (in press)
  • Peer Reviewed
• [Presentation] 長寿関連ミトコンドリアDNA多型と心血管疾患危険因子の重積との関連解析 (2008)
  • Author(s): 小風暁、苅田香苗、吉田正雄、大津忠弘、白澤貴子、櫨場八裕、星野裕美、照屋浩司
  • Organizer: 第67回日本公衆衛生学会総会
  • Place of Presentation: 福岡
  • Year and Date: 20081105-07
• [Presentation] 長寿関連ミトコンドリアDNA多型におけるコーヒー飲用と耐糖能異常との関係解析 (2008)
  • Author(s): 小風暁、石川守、白澤貴子、吉田正雄、本名理恵、照屋浩司、高島豊
  • Organizer: 第78回日本衛生学会総会
  • Place of Presentation: 熊本
  • Year and Date: 20080328-31
• [Presentation] 長寿関連ミトコンドリアDNA多型におけるコーヒー飲用と高血圧症との関係解析 (2007)
  • Author(s): 小風暁、石川守、吉田正雄、増田由美、本名理恵、佐藤正夫、照屋浩司、高島豊
  • Organizer: 第77回日本衛生学会総会
  • Place of Presentation: 大阪
  • Year and Date: 20070325-28
• [Presentation] 長寿関連ミトコンドリアDNA5178C/A多型と飲酒・喫煙習慣との交互作用 (2007)
  • Author(s): 小風暁
  • Organizer: 第3回東京抗加齢医学研究会
  • Place of Presentation: 東京
  • Year and Date: 2007-02-24
• [Presentation] 長寿関連ミトコンドリアDNA5178C/A多型と呼吸機能との関連解析 (2007)
  • Author(s): 小風暁、石川守、松永直美、吉田正雄、佐藤正夫、照屋浩司、増田由美、本名理恵、阿部淑子、高島豊
  • Organizer: 第17回日本疫学会学術総会
  • Place of Presentation: 広島
  • Year and Date: 2007-01-26
• [Presentation] 長寿関連ミトコンドリアDNA5178C/A多型と高血圧症との関連解析 (2006)
  • Author(s): 小風暁、石川守、吉田正雄、増田由美、本名理恵、照屋浩司、高島豊
  • Organizer: 第71回日本民族衛生学会総会
  • Place of Presentation: 那覇
  • Year and Date: 20061109-10
• [Book] In : Columbus F editor. Longevity : Genetics, Diet and Disease
  • Author(s): Akatsuki Kokaze, Mamoru Ishikawa, Naomi Matsunaga, Kanae Karita, Masao Yoshida, Tadahiro Ohtsu, Takako Shirasawa, Yahiro Haseba, Masao Satoh, Koji Teruya, Hiromi Hoshino, Yutaka Takashima
  • Publisher: Longevityassociated mitochondrial DNA 5178 C/A polymorphism modifies the effect of coffee consumption on glucose tolerance in middleaged Japanese men((in press))