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2007 Fiscal Year Final Research Report Summary

The study of amino acid neurotransmitter changes in mood disorder and anxiety disorder assessed by high field proton MRS.

Research Project

Project/Area Number 18591291
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Psychiatric science
Research InstitutionThe University of Tokushima

Principal Investigator

SUMITANI Satsuki  The University of Tokushima, Medical and Dental Hospital, Lecturer (90346594)

Co-Investigator(Kenkyū-buntansha) HRADA Masafumi  The University of Tokushima, Faculty of Meducune, Professer (20228654)
UENO Shu-ich  The University of Tokushima, Faculty of Meducune, Professer (80232768)
Project Period (FY) 2006 – 2007
Keywordsglutamate / GABA / MRS / mood disorder / anxiety disorder
Research Abstract

To investigate the abnormalities of neural function or metabolism in mental disorders, we measured the neurochemical changes in the anterior cingulate (ACC) and bilateral basal ganglia by using high magnetic field (3 Tesla) proton magnetic resonance spectroscopy (MRS) in the patients of mood disorders and anxiety disorders. Especially, we examined changes of the level of amino acid neurotransmitter such as glutamate and gamma amino butyric acid (GABA).
Obsessive-compulsive disorder (OCD) patients had significantly reduced levels of N-acetyl aspertate (NAA) and glutamate (Glu) in the ACC compared to matched controls. NAA levels in the right basal ganglia in OCD patients were higher than those in the left basal ganglia. No differences were found in levels of GABA between OCD patients and controls. Panic disorder patients had significantly higher levels of Glx (glutamate+glutamine) in the right basal ganglia compared to controls. Major depression patients had significantly reduced levels of Glu in the ACC compared to controls.
In the present study we found specific changes of amino acid neurotransmitters in each disorder, although these findings are preliminary that need further study with more samples.

  • Research Products

    (12 results)

All 2008 2007 2006

All Journal Article (7 results) (of which Peer Reviewed: 3 results) Presentation (4 results) Book (1 results)

  • [Journal Article] Lithium effects on brain glutamatergic and GABAergic systems of healthy volunteersas measured by proton magnetic resonance spectroscopy.2008

    • Author(s)
      Sumiko Shibuya-Tayoshi
    • Journal Title

      Pros Neuropsychopharmacol Biol Psychiatry 32

      Pages: 249-256

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Lithium effects on brain glutamatergic and GABAergic systems of healthy volunteers as measured by proton magnetic resonance spectroscopy.2008

    • Author(s)
      Sumiko Shibuya-Tayoshi
    • Journal Title

      Prog Neuropsychopharmacol Biol Psychiatry 32(1)

      Pages: 249-56

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive-compulsive disorder patients.2007

    • Author(s)
      Satsuki Sumitani
    • Journal Title

      Psychiatry Reserch : Neuroimaging 154

      Pages: 85-92

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Activation of the prefrontal cortex during the Trail-Making Test detected with multichannel near-infrared spectroscopy.2007

    • Author(s)
      Sumiko Shibuya-Tayoshi S
    • Journal Title

      Psychiatry Clin Neurosci 61

      Pages: 616-621

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Proton magnetic resonance spectroscopy reveals an abnormality in the anterior cingulate of a subgroup of obsessive-compulsive disorder patients.2007

    • Author(s)
      Satsuki Sumitani
    • Journal Title

      Psychiatry Reserch : Neuroimaging 154(1)

      Pages: 85-92

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Activation of the prefrontal cortex during the Trail-Making Test detected with multichannel near-infrared spectroscopy.2007

    • Author(s)
      Sumiko Shibuya-Tayoshi
    • Journal Title

      Psychiatry Clin 61(6)

      Pages: 616-21

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] A practical guide for the treatment of OCD Neuroscience of OCD2006

    • Author(s)
      Satsuki Sumitani
    • Journal Title

      Kongo Shuppan

      Pages: 95-104

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 近赤外線スペクトロスコピーを用いたストレス負荷時の前頭葉血流変化の検討2007

    • Author(s)
      住谷さっき
    • Organizer
      第29日本生物学的精神医学会
    • Place of Presentation
      札幌
    • Year and Date
      20070711-20071113
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Hemodynamic changes in the prefrontal cortex during mental stress task as measured by multi channel near infrared spectroscopy2007

    • Author(s)
      Satsuki Sumitani
    • Organizer
      The 29st Annual Meeting of Japan Society of Biological Psychiatry
    • Place of Presentation
      Sapporo, Japan
    • Year and Date
      20070711-20070713
    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] 3T proton MRSを用いたOCDの脳内代謝物の検討2006

    • Author(s)
      住谷さっき
    • Organizer
      第28回日本生物学的精神医学会、第36回日本神経精神薬理学会、第49回日本神経化学会合同年会
    • Place of Presentation
      名古屋
    • Year and Date
      20060914-20060916
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] 3T proton MRS investigation in obsessive compulsive disorder2006

    • Author(s)
      Satsuki Sumitani
    • Organizer
      The 28st Annual Meeting of Japan Society of Biological Psychiatry
    • Place of Presentation
      Nagoya, Japan
    • Year and Date
      20060914-20060916
    • Description
      「研究成果報告書概要(欧文)」より
  • [Book] 強迫性障害ハンドブック 強迫性障害のニューロサイエンス2006

    • Author(s)
      住谷さっき
    • Total Pages
      95-104
    • Publisher
      金剛出版
    • Description
      「研究成果報告書概要(和文)」より

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Published: 2010-06-09  

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