Ethanol exposure induces changes of cytoarchitecture of brain-Effects on notch-signal related gene expression

2008 Fiscal Year Self-evaluation Report

• Project/Area Number: 18591292
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Psychiatric science
• Research Institution: Kagawa University
• Principal Investigator: TAKEUCHI Yoshiki Kagawa University, 医学部, 教授 (20116619)
• Project Period (FY): 2006 – 2009
• Keywords: アルコール / 脳組織 / ノッチシグナル伝達 / 遺伝子発現 / 膜タンパク / 神経ネットワーク / 精神神経機能

Research Abstract

神経細胞の発生・分化という最も初期の時点に発現する遺伝子に対するアルコールの影響をNotch-signal伝達系遺伝子を中心として解析し、脳の組織構築異常と精神神経機能障害発症との関連性を明らかにするものである。

Research Products

• [Journal Article] Early postnatal ethanol exposure induces fluctuation in the expression of BDNF mRNA in the developing rat hippocampus Acta Neurobiol Exp (2008)
  • Author(s): Miki T, Kuma H, Yokoyama T, Sumitani K, Matsumoto Y, Kusaka T, Warita K, Wang ZY, Hosomi N, Imagawa T, Bedi KS, Itoh S, Nakamura Y and Takeuchi Y
  • Journal Title: 68(4) Pages: 484-493
  • Peer Reviewed
• [Journal Article] Ethanol neurotoxicity and dentate gyrus development (2008)
  • Author(s): Miki t, Yokoyama T, Sumitani K, Kusaka T, Warita Y, Matsumoto Y, Wang ZY, Wilce PA, Bedi KS, Itoh, S, Takeuchi Y.
  • Journal Title: Congenitaal Anomalies 48(3) Pages: 110-117
  • Peer Reviewed
• [Journal Article] Oligodendrocyte myelin glycoprotein (OMgp) in rat hippocampus is depleted by chronic ethanol consumption (2006)
  • Author(s): Okamoto H, Miki T, Lee KY, Yokoyama T, Kuma H, Wang ZY, Gu H, Li HP, Matsumoto Y, Irawan S, Bedi KS, Nakamura Y, Takeuchi Y.
  • Journal Title: Neurosci Lett 406(1-2) Pages: 76-80
  • Peer Reviewed
• [Journal Article] Changes of parvalbumin immunoreactive neurons and GFAP immunoreactive astrocytes in the rat lateral geniculate nucleus following monocular enucleation (2006)
  • Author(s): Gonzalez D, Satriotomo I, Miki T, Lee KY, Yokoyama T, Touge T, Matsumoto Y, Li HP, Kuriyama S, Takeuchi Y.
  • Journal Title: Neurosci Lett 395(2) Pages: 149-54
  • Peer Reviewed
• [Presentation] A novel enhancer of the PDGF β-receptor gene activated during differentiation of neuroblastoma through Ets and GATA factor Italian Society of Neuroscience (2007)
  • Author(s): Matsumoto Y, Kaneko M, Yang W, Watt F, Warita K, Miki T, Takeuchi Y, Funa K.
  • Place of Presentation: Verona, Italy
  • Year and Date: 20070927-30