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2007 Fiscal Year Final Research Report Summary

Research of incorporation of hepatic perfusion analysis using bigh-spatialresolution MRimaging

Research Project

Project/Area Number 18591337
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Radiation science
Research InstitutionGifu University

Principal Investigator

KANEMATSU Masayuki  Gifu University, University Hospital, associate professor (40252134)

Co-Investigator(Kenkyū-buntansha) KONDO Hiroshi  Gifu University, University Hospital, lecturer (20324311)
COSHIMA Satoshi  Gifu University, University Hospital, Assistant Professor (90402205)
TAKAI Kouji  Gifu University, University Hospital, Clinical Fellow (70402196)
Project Period (FY) 2006 – 2007
KeywordsLiver / Cirrhosis / MR imaging / Perfusion / hepatic blood flow / 肝血流
Research Abstract

We performed perfusion analysis of the liver after giving 5-mL gadolinium-chelate contrast material. After obtaining conventional dynamic. MR imaging of the liver, single-level cine. MR imaging was performed with 5-mL gadolinium contrast for perfusion analysis with dual-input-one-compartment model. We obtained hepatic blood flow ; hepatic, blood volume, mean transit time, and arterial-portal fraction. We evaluated if preceding dynamic MR imaging did not hamper the efficacy of subsequent perfusion imaging. We used algorithm of dual-input one-compartment model (Materne R, et. al. Magn Reson Med 2002 ; 47:135) for perfusion analysis. Several parameters derived from the analysis were correlated with clinical stages of chronic liver damage or cirrhosis, pathological stage of hepatic fibrosis, Child-Pugh score, and ICG15 test value. We found that our methodology for MR perfusion nalysis reflected the degree of hepatic fibrosis to a certain extent. We still need to solve some problems in the technical aspects to increase the accuracy of this technique.

  • Research Products

    (8 results)

All 2007 2006

All Journal Article (6 results) (of which Peer Reviewed: 3 results) Presentation (2 results)

  • [Journal Article] Computer-aided diagnosis of hepatic fibrosis: preliminary evaluation of MRI texture analysis using the finite difference method and an artificial neural network.2007

    • Author(s)
      Kato H, Kanematsu M, Zhang X, Saio M, Kondo H, Goshima S, Fujita H.
    • Journal Title

      Am J Roentgenol 189

      Pages: 117-122

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Gadolinium-enhanced multiphasic 3D MRI of the liver with prospective adaptive navigator correction: phantom study and preliminary clinical evaluation.2007

    • Author(s)
      Kanematsu M, Goshima S, Kon do H, Tsuge Y, Yokoyama R, Kajita K, Onozuka M, Suzuki Y, Van Cauteren M, Moriyama N.
    • Journal Title

      Am J Roentgenol 188

      Pages: 309-316

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Computer-aided diagnosis of hepatic fibrosis : preliminary evaluation of MRI texture analysis using the finite difference method and an artificial neural network2007

    • Author(s)
      Kato, H., Kanematsu, M., Zhang, X., Saio, M., Kondo, H., Goshima, S., Fujita, H
    • Journal Title

      Am J Roentgenol 189(1)

      Pages: 117-22

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Gadolinium-enhanced multiphasic 3D MRI of the liver with prospective adaptive navigator correction : phantom study and preliminary clinical evaluation2007

    • Author(s)
      Kanematsu, M., Goshima, S., Kondo, H., Tsuge, Y., Yokoyama, R., Ralik, K., Onozuka, M., Suzuki, Y., Van, Cautcrcn, M., Moriyama, N
    • Journal Title

      Am J Roentgenol 188(4)

      Pages: 309-16

    • Description
      「研究成果報告書概要(欧文)」より
  • [Journal Article] Double hepatic arterial phase MRI of the liver with switching of reversed centric and centric K-space reordering.2006

    • Author(s)
      Kanematsu M, Goshima S, Kondo H, Yokoyama R, Kajita K, II oshi H, Onozuka M, Nozaki A, Hirano M, Shiratori Y, Moriyama N.
    • Journal Title

      Am J Roentgenol 187

      Pages: 25-32

    • Description
      「研究成果報告書概要(和文)」より
    • Peer Reviewed
  • [Journal Article] Double hepatic arterial phase MRI of the liver with switching of reversed centric and centric K-space reordering2006

    • Author(s)
      Kanematsu, M., Goshima, S., Kondo, II., Yokoyama, R., Kajita, K., IIoshi, II., Onozuka, M., Nozaki, A., Hirano, M., Shiratori, Y., Moriyama, N
    • Journal Title

      Am J Romilgenol 187(2)

      Pages: 464-472

    • Description
      「研究成果報告書概要(欧文)」より
  • [Presentation] Diffusion-weighted MRI of the Hepatic Hemangioma: Relationships between Enhancement Types and Apparent Diffusion Coefficients.2006

    • Author(s)
      Goshima S, Kanematsu M, Kondo H, Tsuge U
    • Organizer
      第92回北米放射線学会
    • Place of Presentation
      シカゴ,米国
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(和文)」より
  • [Presentation] Diffusion Weighted MRI of the Hepatie Hemangioma : Relationships between Enhancement Typcs and Apparcnt Diffusion Cocfficicnts2006

    • Author(s)
      Goshima, S., Kanematsu, M., Kondo, H., Tsuge, U
    • Organizer
      92th Radiological Society of North America
    • Place of Presentation
      Chicago
    • Year and Date
      2006-12-02
    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2010-02-04  

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