2007 Fiscal Year Final Research Report Summary
Research for the mechanisms of the top-down control of the pain and its vulnerability
| Project/Area Number |
18613007
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pain science
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| Research Institution | Osaka University |
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Principal Investigator |
KITAMURA Yuri Osaka University, Graduate School of Medicine, Associate Professor (90294074)
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| Co-Investigator(Kenkyū-buntansha) |
MASHIMO Takashi Osaka University Graduate School of Medicine, 医学系研究科, Professor (10110785)
TAKEDA Masatoshi Osaka University Graduate School of Medicine, 医学系研究科, Professor (00179649)
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| Project Period (FY) |
2006 – 2007
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| Keywords | pain / affection / NIRS / depression |
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| Research Abstract |
Patients with chronic pain frequently suffer from affective disorders, such as depression. Numerous studies have shown a reciprocal relationship between chronic pain and affective disturbance. Each disorder makes patients more vulnerable to the other, although the mechanisms are still unclear. Hypothalamo-pituitary-adrenal axis function might play an important role on the transition from acute to chronic pain. Also personality factors may influence pain processing.
We investigate the mechanisms of the vulnerability for chronic pain by using the neuroimaging method, for example, NIRS; near-infrared spectroscopy, PET scanning and the measurement of eye-movement. Also the institution of the pain clinic center in our hospital could make a go of this study. Further investigations might be needed to establish the evidence-based therapy for chronic pain as well, however, our results must be useful to determine the therapeutical procedure for the patients suffering from severe chronic pain.
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Research Products
(34 results)
