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2008 Fiscal Year Final Research Report

Quantitative analysis of transduction cascade with caged-compounds in the cell.

Research Project

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Project/Area Number 18700382
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionOsaka University

Principal Investigator

TAKEUCHI Hiroko  Osaka University, 大学院・生命機能研究科, 助教 (10324823)

Project Period (FY) 2006 – 2008
Keywords神経科学 / シグナル伝達 / 感覚生理学 / 生体分子 / 生理活性
Research Abstract

嗅細胞シリア上に発現している情報変換チャネルの局在を更に詳細に調査した結果、シリア上に発現している情報変換チャネル(CNGチャネル・Cl(Caチャネル))が一様に分布していることを明らかにし、局所的なUV刺激により、ケージドCaを誘起させたことによる、Cl(Ca)チャネルの分布を明らかにした。本結果は学会・論文で発表を行った。学会発表は、2006年度 : 国際学会2件、国内学会件、2007年度 : 国際学会2件、国内学会1件、2008年度 : 国際学会3件、国内学会2件を行った。論文は全て査読つき雑誌に受理され、2006年The Journal of General Physiology (Chen et al.,)2008年The Neuroscience(Takeuchi H & Kurahashi T)、アロマリサーチ(Sugahara et al.,)に掲載された。

  • Research Products

    (20 results)

All 2009 2008 2007 2006

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (15 results) Book (2 results)

  • [Journal Article] Distribution, amplification, and summation of cyclic nucleotide sensitivities within single olfactory sensory cilia2008

    • Author(s)
      Takeuchi H and Kurahashi T
    • Journal Title

      Journal of Neuroscience 28

      Pages: 766-775

    • Peer Reviewed
  • [Journal Article] 嗅細胞イオンチャネルの定量解析 ノイズ解析の効率を図るプログラム開発 (MS-Windows application executing the non-stationary noise analysis of whole-cell transient current)2008

    • Author(s)
      菅原亜弓・吉田真理子・竹内裕子
    • Journal Title

      Aroma Research Vol9, No3

      Pages: 233-240

    • Peer Reviewed
  • [Journal Article] Odorant inhibition of the olfactory cyclic nucleotide-gated channel with a native molecular assembly2006

    • Author(s)
      Chen TY, Takeuchi H and Kurahashi T
    • Journal Title

      J Gen Physiol. 128(3)

      Pages: 365-71

    • Peer Reviewed
  • [Presentation] ナノバイオマスキングの分子メカニズム解明2008

    • Author(s)
      竹内裕子・引地聰・倉橋隆
    • Organizer
      JASTS (The Japanese Association for the Study of Taste and Smell (Annual meeting)
    • Place of Presentation
      富山
    • Year and Date
      20080917-20
  • [Presentation] 嗅覚マスキングに関わる嗅細胞トランスダクションチャネル抑制機構2008

    • Author(s)
      倉橋隆・竹内裕子・石田浩彦・引地聰
    • Organizer
      JASTS (Annual meeting)
    • Place of Presentation
      富山
    • Year and Date
      20080917-20
  • [Presentation] 嗅細胞における信号増幅を司るCl(Ca)チャネルの特性2008

    • Author(s)
      竹内裕子・倉橋隆
    • Organizer
      JASTS (Annual meeting)
    • Place of Presentation
      富山
    • Year and Date
      20080917-20
  • [Presentation] Visualization. manipulation, recording of nanotube olfactory cilia.2008

    • Author(s)
      Takeuchi, H & Kurahashi, T.
    • Organizer
      ECRO(Congress of European Chemoreception Research Organization)
    • Place of Presentation
      スロベニア(ポルトロズ)
    • Year and Date
      20080903-07
  • [Presentation] CNG block may reduce the olfactory sensitivity.2008

    • Author(s)
      Kurahashi, T., Takeuchi, H., Ishida, H & Hikichi, S.
    • Organizer
      ECRO.
    • Place of Presentation
      スロベニア(ポルトロズ)
    • Year and Date
      20080903-07
  • [Presentation] Mechanism of Olfactory Masking2008

    • Author(s)
      Kurahashi, T., Takeuchi, H., Ishida, H & Hikichi, S
    • Organizer
      ISOT (International Symposium on Olfaction and Taste)
    • Place of Presentation
      米国(サンフランシスコ)
    • Year and Date
      20080721-26
  • [Presentation] Visualization, manipulation and recording of nanotube olfactory cilia.2008

    • Author(s)
      Takeuchi, H. & Kurahashi, T.
    • Organizer
      ISOT
    • Place of Presentation
      米国(サンフランシスコ)
    • Year and Date
      20080721-26
  • [Presentation] Photolysis of Caged Calcium in the Olfactory Sensory Cilia.2008

    • Author(s)
      Takeuchi, H. & Kurahashi, T.
    • Organizer
      Physiological Society of Japan (Annual meeting)
    • Place of Presentation
      東京
    • Year and Date
      20080325-27
  • [Presentation] MS-Windows application executing the non-stationary noise analysis of whole-cell transient current.2008

    • Author(s)
      Sugahara, A., Oi, H., Kurahashi, T & Takeuchi, H.
    • Organizer
      Physiological Society of Japan (Annual meeting)
    • Place of Presentation
      東京
    • Year and Date
      20080325-27
  • [Presentation] Distribution of the Signal Transduction System in the Single Olfactory Cilia.2008

    • Author(s)
      Takeuchi, H & Kurahashi, T. Spatial
    • Organizer
      Physiological Society of Japan (Invitation symposium, Annual meeting)
    • Place of Presentation
      大阪
    • Year and Date
      2008-09-13
  • [Presentation] Distribution of Transduction System with Nano-scale Resolution in Living Olfactory Cilia.2007

    • Author(s)
      Takeuchi, H. & Kurahashi, T. Spatial
    • Organizer
      AchemS (Association for Chemoreception Sciences) (Annual meeting)
    • Place of Presentation
      米国(サラソタ)
    • Year and Date
      20070425-29
  • [Presentation] UV-laser regulation of cytoplasmic factor in living sensory cilia.2007

    • Author(s)
      Takeuchi, H. & Kurahashi, T. Sub-micron
    • Organizer
      Physiological Society of Japan (Annual meeting)
    • Place of Presentation
      大阪
    • Year and Date
      20070320-23
  • [Presentation] Real-time dynamics of molecular elements within the nano-scale olfactory sensory cilia.2006

    • Author(s)
      Takeuchi, H & Kurahashi, T.
    • Organizer
      International Symposium of Olfaction and Taste. (Invitation symposium)
    • Year and Date
      20060711-13
  • [Presentation] MECHANISM OF SIGNL AMPLIFICATION IN THE NEWT OLFACTORY SENSORY CILIA.2006

    • Author(s)
      Takeuchi H & Kurahashi T.
    • Organizer
      AChemS
    • Place of Presentation
      米国(サラソタ)
    • Year and Date
      20060426-30
  • [Presentation] 嗅細胞シリアにおける信号増幅機構2006

    • Author(s)
      竹内裕子・倉橋隆
    • Organizer
      日本生理学会
    • Place of Presentation
      前橋
    • Year and Date
      20060328-30
  • [Book] The Senses: A Comprehensive Reference, Six-Volume Set, 1-6 (Volume 4: Olfaction & Taste 4.28 : Signal Transduction in the Olfactory Receptor Cell)2009

    • Author(s)
      Editoted by Allan Basbaum etal(H Takeuchi , T Kurahashi)
    • Publisher
      Elsevier
  • [Book] 「第4章第2項 : 嗅細胞のイオンチャネル特性」匂いと香りの科学2007

    • Author(s)
      竹内裕子
    • Total Pages
      87-93
    • Publisher
      朝倉書店

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Published: 2010-06-10   Modified: 2016-04-21  

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