2022 Fiscal Year Final Research Report
Development of a method to assess cognitive reserve in Alzheimer's disease using chemical exchange saturation transfer MRI.
| Project/Area Number |
18H02762
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
大久保 真樹 新潟大学, 医歯学系, 教授 (10203738)
鈴木 清隆 新潟大学, 脳研究所, 准教授 (40303169)
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| Project Period (FY) |
2018-04-01 – 2023-03-31
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| Keywords | 磁気共鳴イメージング / アルツハイマー病 / CEST |
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| Outline of Final Research Achievements |
In an animal model of Alzheimer's disease, tissue synaptic density was measured after gluCEST measurement and correlated with gluCEST values. In temporal lobe and hippocampus, we found a decrease in gluCEST preceding a decrease in CBF and a correlation between local gluCEST effects and CBF. Furthermore, we applied this technique to humans, developed 2D gluCEST with 7T MRI, confirmed its reproducibility in normal cases, and confirmed the reduction of hippocampal synapses in dementia cases. We are currently improving the pulse sequence and modifying the image calculation program to shorten the imaging time. Furthermore, we created a 3D imaging sequence and verified the reproducibility of whole-brain synaptic density images in normal cases. 3T MRI application and implantation have been started and normal brains have been successfully imaged.
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| Free Research Field |
神経学・磁気共鳴学
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| Academic Significance and Societal Importance of the Research Achievements |
理論的にさまざまな低分子を通常の形態的MRIに迫る空間分解能で撮像が可能な手法であるCEST-MRIを用い、グルタミン酸をはじめとした神経伝達物質関連分子の濃度マップを作成できれば、変性疾患における種々の局所神経機能を直接反映した機能評価を行うことが可能になると考えられる。これにより、新しい認知機能の無侵襲な客観的診断法として疾患のみならず、老化脳の評価も可能となり、疾患診断・病態把握のみならず、「好ましい老化」を目指したライフスタイルの検証など社会的なインパクトも大きいと考えられる。
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