2022 Fiscal Year Final Research Report

Analysis of stress-induced senescent cells to elucidate the unknown inhibitory mechanism of bone formation

Research Project

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Project/Area Number	18H02986
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Review Section	Basic Section 57040:Regenerative dentistry and dental engineering-related
Research Institution	Osaka Dental University
Principal Investigator	HONDA Yoshitomo 大阪歯科大学, 歯学部, 教授 (90547259)
Co-Investigator(Kenkyū-buntansha)	橋本典也大阪歯科大学, 歯学部, 教授 (20228430) 片岡宏介徳島大学, 大学院医歯薬学研究部(歯学域), 教授 (50283792) 田中知成京都工芸繊維大学, 繊維学系, 准教授 (70585695) 南部隆之大阪歯科大学, 歯学部, 講師 (80367903)
Project Period (FY)	2018-04-01 – 2022-03-31
Keywords	老化細胞
Outline of Final Research Achievements	The aim of this project was to elucidate the behavior and molecular mechanisms of senescent cells and SASP-related factors that inhibit bone formation, which can be useful to develop next-generation bone regeneration therapies free from this inhibition mechanism. Our results revealed that stress-induced premature senescent cells induced by stimuli from lipopolysaccharide or material implantation can be involved in the inhibitory mechanism of bone regeneration.
Free Research Field	再生医療
Academic Significance and Societal Importance of the Research Achievements	本研究の結果、リポ多糖あるいは材料埋入によりストレス誘導性早期老化細胞が誘導され、同細胞が骨再生の阻害に関与している可能性が明らかとなった。これらの知見は、未知なる骨再生阻害メカニズムの解明に繋がりうる知見であり、関連する細胞老化随伴分泌現象因子などの解明が更に進めば、既存の治療法とは異なる新規再生医療やバイオマテリアルの開発などに道を拓くと予想される。