Neural and behavioral mechanisms of sugar binge-like overconsumption in mice

2020 Fiscal Year Final Research Report

• Project/Area Number: 18H03177
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: Osaka University
• Principal Investigator: Yasoshima Yasunobu 大阪大学, 人間科学研究科, 教授 (00273566)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 過剰摂取 / 高嗜好性 / マウスモデル / 消化管ホルモン / 脳幹反応 / 味覚感受性

Outline of Final Research Achievements

Feeding behavior is regulated through multiple physiological mechanisms.But, overconsumption and obesity is observed in many people. Overconsumption is induced by psychosocial factors; little is known how neurobiological factors is involved in overconsumption. In this study, we examined whether binge-like sugar overconsumption in mice was associated with alteration of secretion of a gut hormone and/or brain responsiveness to visceral signals (gut stimulation with nutrient and gut hormone administation). Our data suggest that gut hormone secretion and brain responses to visceral stimulation was altered in mice showing binge-like sugar overconsumption.

Free Research Field

行動神経科学

Academic Significance and Societal Importance of the Research Achievements

本研究での成果から、高ショ糖含有の食物のように高嗜好性の飲食物を過剰摂取してしまうことの背景には、従来からの心理社会的な要因に加えて、不適切な食生活や食事パターンの反復に伴い、身体における摂食調節系の生物機能の変容、特に、摂食抑制系である消化管ホルモンを介した摂食抑制系の機能の変容があること明らかとした。さらに、まだ確定的ではないものの、過食においては摂食進行中に生じる消化管由来の満腹シグナル（within-meal gastrointestinal satiation signal）の作用低下によって、摂食抑制が不十分となり、結果として過食が生じるという可能性が示唆される。