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2021 Fiscal Year Annual Research Report

Development of in silico human model and its application to indoor environmental design

Research Project

Project/Area Number 18H03807
Research InstitutionKyushu University

Principal Investigator

伊藤 一秀  九州大学, 総合理工学研究院, 教授 (20329220)

Project Period (FY) 2018-04-01 – 2022-03-31
Keywordsin silico human model / CFD / 室内空気質 / 経気道暴露 / 経皮暴露
Outline of Annual Research Achievements

本研究は,汚染空気暴露に伴う健康影響を可視化するin silico人体モデルの開発に取り組むもので,特にガス状ならびにエアロゾル状の各種空気汚染物質を対象として,呼吸に伴う経気道暴露,沈着や接触に伴う経皮暴露による人体影響を定量的に予測・評価する数理モデルと,その数値解析用の人体プラットフォームを開発した.具体的には,(1) 各種空気汚染物質を対象とした経気道暴露・経皮暴露の経路と人体暴露メカニズムを数理的に記述する生理的薬物動態(PBPK)モデルを作成した.(2) 皮膚表面幾何形状や呼吸器系幾何形状を精緻に再現したin silico人体モデル開発の基礎となる数値解析用の人体プラットフォームを作成した.これらを統合した上で (3) 経気道暴露・経皮暴露による健康影響・リスクを部位別に定量評価可能なin silico人体モデルを開発した.最終的に (4) in silico人体モデルと熱流体解析技術(CFD)を統合した人体-環境系の総合解析手法を確立し,建材由来の揮発性有機化合物の経気道・経皮曝露予測,電子煙草由来の各種化学物質の1次曝露,2次曝露予測を実施することで,解析事例の蓄積に取り組んだ.

Research Progress Status

令和3年度が最終年度であるため、記入しない。

Strategy for Future Research Activity

令和3年度が最終年度であるため、記入しない。

  • Research Products

    (21 results)

All 2022 2021 Other

All Int'l Joint Research (2 results) Journal Article (14 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 14 results) Presentation (4 results) (of which Int'l Joint Research: 4 results,  Invited: 4 results) Remarks (1 results)

  • [Int'l Joint Research] RMIT University(オーストラリア)

    • Country Name
      AUSTRALIA
    • Counterpart Institution
      RMIT University
  • [Int'l Joint Research] ADRI(オーストラリア)

    • Country Name
      AUSTRALIA
    • Counterpart Institution
      ADRI
  • [Journal Article] Exhaled Jet and Viral-Laden Aerosol Transport from Nasal Sneezing2022

    • Author(s)
      Salati Hana、Fletcher David F.、Khamooshi Mehrdad、Dong Jingliang、Ito Kazuhide、Vahaji Sara、Inthavong Kiao
    • Journal Title

      Aerosol and Air Quality Research

      Volume: 22 Pages: 210338~210338

    • DOI

      10.4209/aaqr.210338

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] SARS-CoV-2 Dynamics in the Mucus Layer of the Human Upper Respiratory Tract Based on Host?Cell Dynamics2022

    • Author(s)
      Li Hanyu、Kuga Kazuki、Ito Kazuhide
    • Journal Title

      Sustainability

      Volume: 14 Pages: 3896~3896

    • DOI

      10.3390/su14073896

    • Peer Reviewed
  • [Journal Article] Dispersion characteristics of oral microbial communities in a built environment2022

    • Author(s)
      Yanagi U、Kato Shinsuke、Nagano Hideaki、Ito Kazuhide、Yamanaka Toshio、Momoi Yoshihisa、Kobayashi Hikaru、Hayama Hirofumi
    • Journal Title

      JAPAN ARCHITECTURAL REVIEW

      Volume: 5(2) Pages: 12261~12261

    • DOI

      10.1002/2475-8876.12261

    • Peer Reviewed
  • [Journal Article] CO2 emission rates from sedentary subjects under controlled laboratory conditions2022

    • Author(s)
      Sakamoto Mitsuharu、Li Mengze、Kuga Kazuki、Ito Kazuhide、Bek? Gabriel、Williams Jonathan、Wargocki Pawel
    • Journal Title

      Building and Environment

      Volume: 211 Pages: 108735~108735

    • DOI

      10.1016/j.buildenv.2021.108735

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The effects of ventilation and temperature on sleep quality and next-day work performance: pilot measurements in a climate chamber2022

    • Author(s)
      Fan Xiaojun、Shao Huiqi、Sakamoto Mitsuharu、Kuga Kazuki、Lan Li、Wyon David P.、Ito Kazuhide、Bivolarova Mariya P.、Liao Chenxi、Wargocki Pawel
    • Journal Title

      Building and Environment

      Volume: 209 Pages: 108666~108666

    • DOI

      10.1016/j.buildenv.2021.108666

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Breathing zone and exhaled air re‐inhalation rate under transient conditions assessed with a computer‐simulated person2022

    • Author(s)
      Kuga Kazuki、Wargocki Pawel、Ito Kazuhide
    • Journal Title

      Indoor Air

      Volume: 32 Pages: 13003~13003

    • DOI

      10.1111/ina.13003

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Pollutant capture efficiencies in and around the opening surface of a fume hood under realistic conditions2022

    • Author(s)
      Muta Ryota、Chung Juyeon、Li Cong、Yoo Sung-Jun、Ito Kazuhide
    • Journal Title

      Indoor and Built Environment

      Volume: 32 Pages: 1~10

    • DOI

      10.1177/1420326X211066538

    • Peer Reviewed
  • [Journal Article] Hygro-thermo-chemical transfer analysis of clothing microclimate using three-dimensional digital clothing model and computer-simulated person2022

    • Author(s)
      Murota Kei、Kang Yujin、Hyodo Sena、Yoo Sung-Jun、Takenouchi Kazuki、Tanabe Shin-ichi、Ito Kazuhide
    • Journal Title

      Indoor and Built Environment

      Volume: 32 Pages: 1~10

    • DOI

      10.1177/1420326X211059449

    • Peer Reviewed
  • [Journal Article] Emission rate of carbon dioxide while sleeping2021

    • Author(s)
      Fan Xiaojun、Sakamoto Mitsuharu、Shao Huiqi、Kuga Kazuki、Ito Kazuhide、Lan Li、Wargocki Pawel
    • Journal Title

      Indoor Air

      Volume: 31 Pages: 2142~2157

    • DOI

      10.1111/ina.12911

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] A critical overview of adsorption kinetics for cooling and refrigeration systems2021

    • Author(s)
      Muttakin Mahbubul、Pal Animesh、Rupa Mahua Jahan、Ito Kazuhide、Saha Bidyut Baran
    • Journal Title

      Advances in Colloid and Interface Science

      Volume: 294 Pages: 102468~102468

    • DOI

      10.1016/j.cis.2021.102468

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Hybrid emergency ventilation system for controlling inhaled contaminant dose in the case of chemical leakage2021

    • Author(s)
      Ichimiya Shun、Murga Alicia、Yoo Sung-Jun、Sumiyoshi Eisaku、Harashima Hiroshi、Long Zhengwei、Ito Kazuhide
    • Journal Title

      Indoor and Built Environment

      Volume: 31 Pages: 696~709

    • DOI

      10.1177/1420326X211026360

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Computational fluid dynamics comparison of impaired breathing function in French bulldogs with nostril stenosis and an examination of the efficacy of rhinoplasty2021

    • Author(s)
      Khoa Nguyen Dang、Phuong Nguyen Lu、Tani Kenji、Inthavong Kiao、Ito Kazuhide
    • Journal Title

      Computers in Biology and Medicine

      Volume: 134 Pages: 104398~104398

    • DOI

      10.1016/j.compbiomed.2021.104398

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The effects of warmth and CO2 concentration, with and without bioeffluents, on the emission of CO2 by occupants and physiological responses2021

    • Author(s)
      Kuga Kazuki、Ito Kazuhide、Wargocki Pawel
    • Journal Title

      Indoor Air

      Volume: 31 Pages: 2176~2187

    • DOI

      10.1111/ina.12852

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Secondary indoor air pollution and passive smoking associated with cannabis smoking using electric cigarette device?demonstrative in silico study2021

    • Author(s)
      Kuga Kazuki、Ito Kazuhide、Chen Wenhao、Wang Ping、Fowles Jeff、Kumagai Kazukiyo
    • Journal Title

      PLOS Computational Biology

      Volume: 17 Pages: 1009004~1009004

    • DOI

      10.1371/journal.pcbi.1009004

    • Peer Reviewed / Int'l Joint Research
  • [Presentation] Computer simulated person for predicting inhalation exposure and airborne infection2022

    • Author(s)
      Kazuhide Ito
    • Organizer
      SCONNA 2022
    • Int'l Joint Research / Invited
  • [Presentation] In Silico Modeling for Airborne Transmission of Inhaled Virus-Laden Droplets and Host Cell Dynamics in the Respiratory System2021

    • Author(s)
      Kazuhide Ito
    • Organizer
      TSIEQ 2021
    • Int'l Joint Research / Invited
  • [Presentation] Integrated CFD and In Silico Modeling for Airborne Transmission Analysis in Indoor Environment2021

    • Author(s)
      Kazuhide Ito
    • Organizer
      ISHVAC 2021
    • Int'l Joint Research / Invited
  • [Presentation] In Silico Human Model based Indoor Design for Healthy Environment2021

    • Author(s)
      Kazuhide Ito
    • Organizer
      2021 International Conference of Green Building and Low Carbon Technology
    • Int'l Joint Research / Invited
  • [Remarks] 九州大学総合理工学研究院 伊藤研究室

    • URL

      http://www.phe-kyudai.jp/index.html

URL: 

Published: 2022-12-28  

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