2020 Fiscal Year Final Research Report

Multi-omics analysis for hepato-biliary-pancreatic cancers

Research Project

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Project/Area Number	18H04049
Research Category	Grant-in-Aid for Scientific Research (A)
Allocation Type	Single-year Grants
Section	一般
Review Section	Medium-sized Section 53:Organ-based internal medicine and related fields
Research Institution	Institute of Physical and Chemical Research
Principal Investigator	Nakagawa Hidewaki 国立研究開発法人理化学研究所, 生命医科学研究センター, チームリーダー (50361621)
Co-Investigator(Kenkyū-buntansha)	井元清哉東京大学, 医科学研究所, 教授 (10345027) 山上裕機和歌山県立医科大学, 医学部, 教授 (20191190) 相方浩広島大学, 医系科学研究科(医), 准教授 (30403512) 中村透北海道大学, 医学研究院, 助教 (70645796) 二階堂愛国立研究開発法人理化学研究所, 生命機能科学研究センター, チームリーダー (00383290)
Project Period (FY)	2018-04-01 – 2021-03-31
Keywords	肝胆膵がん / ゲノム / オミックス解析 / 分子分類
Outline of Final Research Achievements	For liver cancer, we performed immune-genomic analysis and classified it into four subgroups in the aspects of immune suppression mechanism. Proteome analysis classified liver cancers in the aspects of drug therapies. We clarified the cellular plasticity mechanism of combined types of liver cancer with HCC and cholangiocarcinoma. For cholagiocarcinoma, we identified drugs which can be applicable in each patient by using genomic and transcriptomic data. For pancreatic cancer, we performed genomic and transcriptomic analysis with microbiome analysis on small intestine and examined any effect of chemotherapy on pancreatic cancer immunology and microbiome.
Free Research Field	腫瘍医科学
Academic Significance and Societal Importance of the Research Achievements	本研究は、最も難治性である肝胆膵がんに照準をしぼり、そのゲノム、RNA,たんぱく質、免疫、腸内細菌叢といった多元的なオミックス解析を行い、肝胆膵がんの分子分類を確立し、また、個別化治療の提案をおこなうものである。