Mechanism of follicle selection in mammalian ovary- Is the selection induced by inhibin?

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K06306
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 44040:Morphology and anatomical structure-related
• Research Institution: Hokkaido University
• Principal Investigator: OGIWARA Katsueki 北海道大学, 理学研究院, 准教授 (00422006)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: 濾胞選択 / 卵巣 / アポトーシス / エストラジオール / インヒビン / アクチビン

Outline of Final Research Achievements

The present study aims to elucidate a molecular mechanism of mouse follicle selection. Most primordial follicles that have started growing die by apoptosis, and only the survived follicles are ovulated. Many investigators have studied about it, but the detail is still unclear. The present study was carried out using a hormone substance that is suggested to suppress follicle selection (apoptosis). The results suggest that production and secretion of estradiol 17b (E2) are regulated by Activin-A induced by FSH and that E2 is involved in apoptosis. Based on the results, we propose a model that apoptosis is controlled by E2.

Free Research Field

生殖生物学

Academic Significance and Societal Importance of the Research Achievements

本研究課題の成果は未だにその分子機構が解明されていない濾胞選択の分子機構を解明するための大きな一歩となる成果であり、その学術的意義は大きい。また、濾胞選択は良質な卵を選択し排卵させるシステムと考えられていることから少しでも良質な卵を獲得したい畜産分野で積極的に研究が行われている。本研究成果は、これらの分野にも影響を与える成果であり、その意義は大きいと考える。