2020 Fiscal Year Final Research Report

APT imaging of benign ovarian cystic lesion: usefulness for early diagnosis

Research Project

PDF

Project/Area Number	18K07683
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Review Section	Basic Section 52040:Radiological sciences-related
Research Institution	Kyushu University
Principal Investigator	Ishimatsu Keisuke 九州大学, 大学病院, 医員 (20800147)
Co-Investigator(Kenkyū-buntansha)	西江昭弘九州大学, 医学研究院, 教授 (20457427) 浅山良樹大分大学, 医学部, 教授 (40380414) 石神康生九州大学, 医学研究院, 教授 (10403916) 牛島泰宏九州大学, 大学病院, 助教 (40432934) 柿原大輔九州大学, 大学病院, 講師 (80529818) 中山智博九州大学, 医学研究院, 講師 (70419571) 藤田展宏九州大学, 大学病院, 助教 (30610612) 森田孝一郎九州大学, 大学病院, 医員 (20725858) 高尾誠一朗九州大学, 大学病院, 医員 (70803443) 本田浩九州大学, 大学病院, 教授 (90145433)
Project Period (FY)	2018-04-01 – 2021-03-31
Keywords	卵巣
Outline of Final Research Achievements	Amide Proton Transfer imaging, a novel molecular imaging technique for MRI, provides information reflecting the concentration of mobile proteins/peptides in the tissue. It is known that some benign ovarian cystic lesions can be malignant p while others have no malignant potential. However, it is sometimes difficult to distinguish them using conventional imaging techniques. Therefore, we conducted APT imaging (takes less than 5 minutes scan) in addition to regular MRI in our institution, and the results showed that it was more useful than conventional imaging methods in distinguishing these cysts. These results were presented in an oral presentation at the International Society of Magnetic Resonance in Medicine in 2018. Further, it published in a paper in 2019.
Free Research Field	放射線科学
Academic Significance and Societal Importance of the Research Achievements	Amide Proton Transferイメージングを用いることで、良性卵巣嚢胞性病変で悪性化の可能性のあるもの（漿液性嚢胞性腺腫・粘液性嚢胞腺腫）と悪性化せず治療の必要がないもの（機能性嚢胞）が従来よりも早期に診断できる可能性がある。これによって悪性化の可能性のある病変を悪性化する前のより早期に治療できるようになることが期待される。