2020 Fiscal Year Final Research Report
A novel treatment targeting cancer stem-like cells in esophageal squamous cell carcinoma
| Project/Area Number |
18K07959
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53010:Gastroenterology-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2018-04-01 – 2021-03-31
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| Keywords | 癌幹細胞 / 食道扁平上皮癌 |
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| Outline of Final Research Achievements |
The authors have identified CD24Low/CD44High cells as cancer stem-like cells (CSCs) in esophageal squamous cell carcinoma (ESCC). Furthermore, the authors have reported that FGF-2/FGFR/Erk pathway has critical roles in regulating CSCs in ESCC. In the present study, they have shown that FGFR/Erk inhibitors decrease CSCs in ESCC and restore sensitivity to anticancer drugs and radiation in experiments using organoid culture system, organotypic 3D culture system and xenograft experiments. FGFR/Erk inhibitors could be used as a novel therapy targeting CSCs in ESCC.
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| Free Research Field |
消化器内科学、腫瘍学
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| Academic Significance and Societal Importance of the Research Achievements |
多くの癌において分子標的薬が実用化されている中、進行食道扁平上皮癌（ESCC）においては有効な分子標的薬が未だ無いのが現状である。本研究は進行ESCC症例に対する集学的な新規治療法開発の萌芽となる可能性がある。また、本研究で用いた食道扁平上皮癌３次元培養、オーガノイド、動物モデルは生体内に近い形での癌細胞の培養がin vitroで可能であり、通常培養法では困難な癌研究を飛躍的に向上させてきた。これらの研究手法により今後のESCC研究のさらなる向上が期待される。
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