Systemic and cardiac response to fasting and heart failure

2022 Fiscal Year Final Research Report

• Project/Area Number: 18K08104
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Kyoto University
• Principal Investigator: Kato Takao 京都大学, 医学研究科, 准教授 (30583877)
• Project Period (FY): 2018-04-01 – 2023-03-31
• Keywords: 心不全 / 栄養 / 飢餓 / 絶食

Outline of Final Research Achievements

The purpose of the study was to test the question, "Is heart failure a response to cardiac and systemic starvation?" The objective was to test the question, "Is heart failure a cardiac and systemic starvation response? New measurement techniques allowed us to create a database of starvation responses, and we found that fasting induced cardiac dysfunction. The genetic changes showed some common behavior with heart failure models and human heart failure microarrays. Clustering was possible based on analyses including transcriptomes and metabolomes of liver, skeletal muscle, and cardiac muscle. The multilevel integrated analysis suggested that the systems involved in Gap junction and heme synthesis are decreased as part of the mechanism of cardiac dysfunction in this model, and may be a potential therapeutic target.

Free Research Field

心不全

Academic Significance and Societal Importance of the Research Achievements

心不全の一部は飢餓に対する反応であることが考えられ、大きな社会的な問題となっている心不全に対する、栄養学的アプローチの基礎的根拠を与えると考えられる。本モデルの心機能低下の機序の一部として、Gap junctionに関わる系、ヘム合成に関わる系の低下が示唆され、治療ターゲットとなる可能性がある。
また、多階層の解析手段は、臓器の連関を解く有用なツールであることが示され、他の疾患モデルの解析に有用であると考えられる。