2022 Fiscal Year Final Research Report
Hemodynamic in pregnant women and fetus in Fontan circulation
| Project/Area Number |
18K08109
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Review Section |
Basic Section 53020:Cardiology-related
|
|---|
| Research Institution | Kyushu University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
山崎 誘三 九州大学, 大学病院, 助教 (00643347)
坂本 一郎 九州大学, 大学病院, 学術研究員 (90616616)
|
|---|
| Project Period (FY) |
2018-04-01 – 2023-03-31
|
| Keywords | Fontan / 妊娠 |
|---|
| Outline of Final Research Achievements |
This cohort had relatively stable Fontan circulation. However, heart failur occurred during pregnancy. There was no arrhythmia event. Anticoagulated therapy was perfomred during pregnancy. although there were no thrombotic events, hemorrhagic complications were important issue. Circulating plasma may impact on Atrioventricular valve regurgitation and elevated BNP. Neonates tended to be born prematurely and with low birth weight. In the fetuses, the Tei-index tended to be elevated, suggesting the influence of placental circulation.
|
| Free Research Field |
Cardiology
|
| Academic Significance and Societal Importance of the Research Achievements |
Fontan術後の予後が改善されてくる中で、成人に到達する患者も増加しておきており、小児から成人へという従来の移行期医療に加え、先天性心疾患患者が妊娠し出産をするという周産期における移行期医療も重要性が増している。しかしながら、どのように管理するのが適切なのかはまだ確立されていない。本研究によって、Fontan循環での妊娠による血行動態の変化や妊娠の転帰の一部を明らかにすることができ、今後の治療方針の確立につながると
いう意味で意義があったと考える。
|
