• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2023 Fiscal Year Annual Research Report

蛍光スペクトル解析胸腔鏡と5-ALAを応用した新規肺腫瘍マーキング法の開発

Research Project

Project/Area Number 18K08774
Research InstitutionHokkaido University

Principal Investigator

新垣 雅人  北海道大学, 大学病院, 講師 (30788245)

Co-Investigator(Kenkyū-buntansha) 加藤 達哉  北海道大学, 大学病院, 教授 (20624232)
海老原 裕磨  北海道大学, 大学病院, 特任教授 (50632981)
Project Period (FY) 2022-01-04 – 2024-03-31
KeywordsPhotosesityzer / 内視鏡 / PDT / 光線力学的治療 / レーザー / アブスコパル効果
Outline of Annual Research Achievements

2019年4月よりカナダに留学し2023年1月に帰国した。このカナダへの留学期間中本課題は中断となっており、2023年1月に帰国してから再開としている。2018年度から2021年度までに胸腔鏡や気管支鏡下の胸部悪性腫瘍の同定も含めた、レーザーと光増感剤を使用した胸部悪性腫瘍に対する光線力学的治療(PDT)に関する研究の主要部分はすでに終了しており、徐々に論文化されている(①Aragaki M, Lou J, et al.Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy. Biomaterials. 2023、②Gregor A,Aragaki M, et al.Preclinical feasibility of bronchoscopic fluorescence-guided lung sentinel lymph node mapping. JTCVS. 2023、③Ishiwata T,Aragaki M, et al, Transbronchial real-time lung tumor localization with folate receptor-targeted near-infrared molecular imaging: A proof of concept study in animal models. JTCVS. 2023)。2023年度は共同研究者との今後の研究に関するミーティング、データ作成・整理などを行い、本研究結果を基盤とした新しい研究の計画も立てた

  • Research Products

    (9 results)

All 2024 2023 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (3 results)

  • [Int'l Joint Research] トロント大学(カナダ)

    • Country Name
      CANADA
    • Counterpart Institution
      トロント大学
  • [Journal Article] Imaging Microbubbles With Contrast-Enhanced Endobronchial Ultrasound2024

    • Author(s)
      McGrath Sean、Shen Yu-Jack、Aragaki Masato、Motooka Yamato、Koga Takamasa、Gregor Alexander、Bernards Nicholas、Cherin Emmanuel、Demore Christine E.M.、Yasufuku Kazuhiro、Matsuura Naomi
    • Journal Title

      Ultrasound in Medicine and Biology

      Volume: 50 Pages: 28~38

    • DOI

      10.1016/j.ultrasmedbio.2023.08.020

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessment of effectiveness and safety of thrombolytic therapy to pulmonary emboli by endobronchial ultrasound-guided transbronchial needle injection2023

    • Author(s)
      Sata Yuki、Aragaki Masato、Inage Terunaga、Bernards Nicholas、Gregor Alexander、Kitazawa Shinsuke、Yokote Fumi、Koga Takamasa、Ogawa Hiroyuki、Hiraishi Yoshihisa、Ishiwata Tsukasa、Effat Andrew、Kazlovich Kate、Chan Harley、Yoshino Ichiro、Yasufuku Kazuhiro
    • Journal Title

      JTCVS Techniques

      Volume: 22 Pages: 292~304

    • DOI

      10.1016/j.xjtc.2023.09.005

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Optimization of thrombolytic dose for treatment of pulmonary emboli using endobronchial ultrasound-guided transbronchial needle injection2023

    • Author(s)
      Aragaki Masato、Inage Terunaga、Ishiwata Tsukasa、Gregor Alexander、Bernards Nicholas、Kato Tatsuya、Yasufuku Kazuhiro
    • Journal Title

      The Journal of Thoracic and Cardiovascular Surgery

      Volume: 165 Pages: e210~e221

    • DOI

      10.1016/j.jtcvs.2022.08.044

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transbronchial real-time lung tumor localization with folate receptor-targeted near-infrared molecular imaging: A proof of concept study in animal models2023

    • Author(s)
      Ishiwata Tsukasa、Hiraishi Yoshihisa、Bernards Nicholas、Sata Yuki、Gregor Alexander、Aragaki Masato、Yasufuku Kazuhiro
    • Journal Title

      The Journal of Thoracic and Cardiovascular Surgery

      Volume: 165 Pages: e240~e251

    • DOI

      10.1016/j.jtcvs.2022.09.042

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Repeated photodynamic therapy mediates the abscopal effect through multiple innate and adaptive immune responses with and without immune checkpoint therapy2023

    • Author(s)
      Lou Jenny、Aragaki Masato、Bernards Nicholas、Chee Tess、Gregor Alexander、Hiraishi Yoshihisa、Ishiwata Tsukasa、Leung Chelsea、Ding Lili、Kitazawa Shinsuke、Koga Takamasa、Sata Yuki、Ogawa Hiroyuki、Chen Juan、Kato Tatsuya、Yasufuku Kazuhiro、Zheng Gang
    • Journal Title

      Biomaterials

      Volume: 292 Pages: 121918~121918

    • DOI

      10.1016/j.biomaterials.2022.121918

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 反復光線力学的療法は、アブスコパル効果を介して胸部悪性腫瘍の遠隔転移巣を制御する-マウスモデルでの検討2023

    • Author(s)
      新垣 雅人, Lou, Jenny, Bernards Nicholas, 石綿 司, Gregor Alexander, 加藤 達哉, Zheng, Gang, 安福 和弘
    • Organizer
      第123回 日本外科学会定期学術集会
  • [Presentation] 肺動脈血栓塞栓症に対する超音波気管支鏡下薬剤注入療法の確立を目指して―血栓溶解剤至適投与量の検討2023

    • Author(s)
      新垣雅人,稲毛輝長,石綿 司,Gregor Alexander Bernards Nicholas,加藤達哉,安福和弘
    • Organizer
      題46回 日本呼吸器内視鏡学会学術集会
  • [Presentation] 免疫療法による光線力学的療法後アブスコパル効果の増強作用と免疫学的機序の解析-マウスモデルでの検討2023

    • Author(s)
      新垣 雅人, Lou Jenny, Bernards Nicholas, 石綿 司, Gregor Alexander, 加藤 達哉 Zheng Gang, 安福 和弘
    • Organizer
      第64回 日本肺癌学会学術集会

URL: 

Published: 2024-12-25  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi