Investigation of intersexual transplantation of uterine and ovaries

2021 Fiscal Year Final Research Report

• Project/Area Number: 18K09482
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 56070:Plastic and reconstructive surgery-related
• Research Institution: Okayama University
• Principal Investigator: Namba Yuzaburo 岡山大学, 大学病院, 教授 (00335605)
• Project Period (FY): 2018-04-01 – 2022-03-31
• Keywords: 子宮移植 / 子宮卵巣移植 / 性同一性障害 / 異性間移植

Outline of Final Research Achievements

We aimed to establish a uterine and ovaries transplantation model. First, we attempted to establish the details of operative procedure. Female rats are generally smaller than male rats, thus we had difficulty in the vascular anastomosis and harvesting the grafts. In order to shorten the operative time, we evaluated the blood flow of the grafts in the short and long terms in various ischemic situation. As a result, we decided to perform unilateral uterine transplantation with ipsilateral uterine arteries and veins. However, it was very difficult to maintain the blood flow in the long-term course even after autologous transplantation. Therefore, we considered it also hard to accomplish the good long-term course of intersexual uterine transplantation.

Free Research Field

形成外科学

Academic Significance and Societal Importance of the Research Achievements

今回研究成果として良好な子宮卵巣移植の動物モデルを作製出来ていれば、①性別適合手術時にトランス男性患者から摘出した子宮を、子宮移植を求める患者へ移植することで、子宮移植のドナー候補を増やすことが可能となる、②トランス女性やアンドロゲン不応症などの患者に付属器と同時に移植することでの妊娠を期待することも可能となる、といった意義に繋がったかもしれないが、今回の研究では良好な結果を得られず終了している。