Nutritional solution for chronic kidney disease through the dual maintenance mechanism of renal and skeletal muscle

2020 Fiscal Year Final Research Report

• Project/Area Number: 18K17966
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59040:Nutrition science and health science-related
• Research Institution: The University of Tokushima
• Principal Investigator: KANEKO Ichiro 徳島大学, 大学院医歯薬学研究部(医学域), 助教 (40389515)
• Project Period (FY): 2018-04-01 – 2021-03-31
• Keywords: ビタミンD / FGF19 / 慢性腎臓病 / サルコペニア

Outline of Final Research Achievements

In patients with chronic kidney disease (CKD), we investigated the improvement of skeletal muscle atrophy without depending on protein intake because of renal function decline due to protein load. It was suggested that the combined use of fibroblast growth factor 19 (FGF19) and vitamin D can maintain renal function and prevent skeletal muscle atrophy in CKD patients. Since the decline in renal function occurs irreversibly, these results can be expected to lead to new nutritional management for CKD or dialysis patients.

Free Research Field

分子栄養学

Academic Significance and Societal Importance of the Research Achievements

本研究では、ビタミンDによる腎保護および筋萎縮改善メカニズムを明らかにした。。また、筋合成に重要な因子としてFGF19の作用を明らかにし、特に慢性腎臓病患者にとってビタミンDと併用することでサルコペニア改善に有用であることが示唆された。近年、慢性腎臓病や透析患者の増加が著しく、本研究の成果は、普段の食事や治療時の栄養管理の改善を介して、健康寿命の延長に貢献できると考えられる。