2022 Fiscal Year Final Research Report
Field-based toxicological mechanism analysis of emerging and re-emerging environmental pollution in Africa.
| Project/Area Number |
18KK0287
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| Research Category |
Fund for the Promotion of Joint International Research (Fostering Joint International Research (B))
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 63:Environmental analyses and evaluation and related fields
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
池中 良徳 北海道大学, 獣医学研究院, 教授 (40543509)
中山 翔太 北海道大学, 獣医学研究院, 准教授 (90647629)
中田 北斗 北海道大学, 獣医学研究院, 博士研究員 (60815273)
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| Project Period (FY) |
2018-10-09 – 2023-03-31
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| Keywords | アフリカ / 環境汚染 / 農薬 / 重金属 |
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| Outline of Final Research Achievements |
In recent years, African countries have been promoting rapid resource development. As a result, rapid pollution of the environment has become apparent, and health hazards to ecosystems, livestock, and humans have been reported in some countries. For example, most of the 230,000 lead poisoning deaths worldwide occur in developing countries such as Africa, and the WHO has indicated that lead should be a priority. In this study, we analyzed exposure to heavy metals and pesticides using Zambia and South Africa as models to determine the actual effects on humans and animals that are occurring at the field level.
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| Free Research Field |
環境毒性学
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| Academic Significance and Societal Importance of the Research Achievements |
アフリカにおける環境汚染はブラックボックスとなっているが、本研究ではヒトや動物が直接受けている環境汚染とその生体影響について明らかにした。実際に症状が顕在化する前にどのような変化が起こりえるのかを遺伝子レベルやメタボローム解析により報告した。重金属ではひとで起こっているゲノムの修飾の変化を明らかにし、また、農薬では胆汁酸に係る変化を新たに報告した。
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