2011 Fiscal Year Final Research Report
Structural biology of ion transporters
| Project/Area Number |
19002013
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OGAWA Haruo 東京大学, 分子細胞生物学研究所, 准教授 (40292726)
TSUDA Takeo 東京大学, 分子細胞生物学研究所, 助教 (10345233)
KONDOU Youhei 東京大学, 分子細胞生物学研究所, 助教 (30436604)
ISHIKITA Hiroshi 東京大学, 分子細胞生物学研究所, 助教 (00508111)
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| Co-Investigator(Renkei-kenkyūsha) |
MIMURA Hisatoshi 東京大学, 分子細胞生物学研究所, 助教 (30463904)
KANAI Ryuta 東京大学, 分子細胞生物学研究所, 助教 (50598472)
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| Project Period (FY) |
2007 – 2011
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| Keywords | イオンポンプ / 膜蛋白質 / 結晶解析 |
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| Research Abstract |
In living organisms, concentrations of ions differ substantially across the membranes and form the basis for biological activity such as nerve excitation and muscle contraction. Such differences in ion concentrations are maintained by ion pump proteins, which reside in biological membrane. In this research project, we focused on the calcium and the sodium pumps, and carried out the crystal structure analyses of the reaction intermediates, development of a high yield expression system of mammalian membrane proteins, and that of methods for visualizing biological membranes in the crystals, aiming at the complete understanding of the mechanism and development of drugs for the ion pumps.
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