2011 Fiscal Year Final Research Report
Molecular Analysis of Light-signaling and Circadian Rhythm in theBrain
| Project/Area Number |
19107002
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KOJIMA Daisuke 東京大学, 大学院・理学系研究科, 講師 (60376530)
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| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Daisuke 東京大学, 大学院・理学系研究科, 講師 (60376530)
SHIMIZU Kimiko 東京大学, 大学院・理学系研究科, 助教 (50451828)
YOSHITANE Hikari 東京大学, 大学院・理学系研究科, 助教 (70569920)
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| Project Period (FY) |
2007 – 2011
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| Keywords | 脳・神経 / 視覚 / 光 / シグナル伝達 / サーカディアンリズム / 転写因子 / タンパク質リン酸化 / 松果体 |
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| Research Abstract |
In this study, we aimed at molecular level understanding of the photoreception systems in animals. Particularly we raised three projects: 1) Elucidation of unique gene networks that specify photoreceptor functions between the pineal gland and the retina, 2) Elucidation of the regulatory mechanisms for circadian clock phase, 3) Characterization of light-response properties in photoreceptive cells in the retina. The major outputs from our studies are: 1) Identification of transcription factors that govern the pineal specific gene expression, 2) Identification of multiple proteins regulating the clock phase and elucidation of the underlying mechanisms for the phase-shift, 3) Clarification of a mechanism that provides a difference of photoreceptive properties between retinal rods and cones.
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[Journal Article] (*equal contribution; #corresponding authors)UV-sensitive photoreceptor protein OPN5 in humans and mice2011
Author(s)
Kojima,D.*#, Mori,S.*, Torii,M.*, Wada,A., Morishita,R. & Fukada,Y.#
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Journal Title
PLoS One
Volume: 6
Pages: e26388
DOI
Peer Reviewed
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